The Impact of the Phase III Pipeline: Future Projections and Market Disruptions

Table of Contents

Chapter One: Executive Summary

• Scope and Methodology
• Potential Market Opportunity
• Issues and Trends Affecting Market
• Leading Competitors

Chapter Two: Introduction Drugs in Phase III Development

• Introduction
• Drug Development Overview
  • Phases of Drug Development
  • Benefits and Risks of Phase III Development
  • Benefits
  • Risks
  • Randomization
  • Clinical Trial Protocol
• Orphan Drugs
• Fast Track Drug Status
• Biotechnology Drug Development
• Mergers, Acquisitions, and Collaborations
• Contributors To R&D Success
• R&D Spending
  • Contract Research Organizations

Chapter Three: Cardiovascular Drugs: Phase III Development Analysis

• Overview
  • Heart
  • Circulatory System
  • Cardiac Cycle
  • Isovolumic Contraction
  • Ventricular Ejection
  • Isovolumic Relaxation
  • Coronary Circulation
  • Cardiac Myocytes
• o
  • Contraction
  • Calcium Role in Contraction
  • Relaxation
  • Cardiac Energy Metabolism
  • Cardiac Output
  • Conditions
  • Angina Pectoris
  • Arrhythmia
  • Atherosclerosis
  • Congestive Heart Failure
  • Coronary Artery Disease
  • Hypertension
  • Myocardial Infarction
  • Incidence of Conditions
• Products in Development
  • AGI-1067
  • Alfimeprase
  • Ambrisentan
  • Angiomax
  • Atrixra
  • Azimilide
  • Celacade
  • Clevelox
  • Conivaptan
  • CP-529, 414 (Torcetrapib/Atorvastatin)
  • Dabigatran Extexilate
  • Darusentan
  • Dronedarone
  • Exanta
  • Enoximone capsules
  • Idraparinux
  • Integrilin
  • Lercanidipine (Zanidip)
  • OPC-41061
  • Pexelizumab
  • Prasugrel
  • Propiony-l-carnitine
  • Ranexa
  • Resten NG
  • RSD 1235 IV
  • Simdax
  • SPP101
  • Tecadenoson
  • Tedisamil (Pulzium)
  • Thelin
• Market Size and Growth
• Competitive Analysis

Chapter Four: Neuropsychotherapeutic Drugs: Phase III Development Analysis

• Overview
  • Structural Organization of the Neurological System
• Types of Neuropsychotherapeutic Diseases and Disorders
  • Alzheimer's Disease and Dementia
  • Traumatic Brain Injury
  • Cerebrovascular Disease and Stroke
  • Ischemic Stroke
  • Hemorrhagic Stroke
  • Cerebral Palsy
  • Parkinson's Disease
  • Huntington's Disease
  • Myasthenia Gravis
  • Tic and Tourette's Syndrome
  • Periodic Limb Movement Disorder and Restless Leg Syndrome
  • Seizures
  • Generalized Seizures
  • Partial Seizures
  • Aura/Prodrome
  • Multiple Sclerosis
  • Amyotrophic Lateral Sclerosis
  • Spinal Cord Injury
  • Guillian-Barre Syndrome
  • Bell's Palsy
  • Anxiety Disorders
  • Panic Disorder
  • Post-traumatic Stress Disorder
  • Specific and Social Phobias
  • Attention Deficit Hyperactivity Disorder
  • Bipolar Disorder
  • Cyclothymic Disorder
  • Borderline Personality Disorder
  • Depression
  • Eating Disorders
  • Anorexia Nervosa
  • Bulimia Nervosa
  • Obsessive-Compulsive Disorder
  • Schizophrenia
• o
  • Sleep Disorders
  • Insomnia
  • Narcolepsy
  • Parasomnia
  • Substance Abuse
  • Alcohol Abuse
  • Drug Abuse
  • Incidence of Conditions
• Products in Development
  • AERx Inhaled Morphine
  • Alcar
  • ALGRX 3268
  • Alzhemed
  • Ampligen
  • Antegren
  • Aquavan
  • Asenapine
  • Bicifadine
  • Bifeprunox
  • CEP 1347
  • Cerovive
  • Chronogesic
  • Citicoline
  • Corlux
  • DAS-431
  • DU 127090
  • DVS-223
  • Dynastat
  • Fampridine
  • Flurizan
  • Gaboxadol
  • Iloperidone
  • Indiplon
  • KW-6002
  • Lacosamide
  • Miraxion
  • MT 100
  • MT 300
  • Mylinax
  • Neurodex
  • NGX-4010
  • NRP104
  • Nuvigil
  • ONO-2506
  • Org 25969
  • Oxytrex
  • Pagoclone
  • Phenserine
  • PRX-00023
  • Rapinyl
  • Rasagiline
  • Remoxy
  • ReoPro
  • Requip CR
  • Rotigotine CDS
  • Saredutant
  • SGS111
  • Silenor
  • SLV308
  • SPD 503
  • Spheramine
  • SR58611
  • Teriflunomide
  • Tramadol
  • Trexima
  • Xaliproden
  • Zelpar
• Market Size and Growth
• Competitive Analysis

Chapter Five: Infectious Disease: Phase III Development Analysis

• Overview
• Conditions
  • Fungi
  • Viruses
  • Hepatitis
  • Hepatitis A
  • Hepatitis B
  • Hepatitis C
  • Hepatitis D
  • Hepatitis E
  • Hepatitis G
  • Herpes Simplex
  • Epstein-Barr Virus (Mononucleosis)
  • Influenza
  • Other Significant Viruses
  • Human Papilloma Virus
  • Cytomegalovirus
  • Respiratory Syncytial Virus
  • Hantavirus
  • Yellow Fever
  • Rotavirus
  • Parvovirus
  • Incidence of Conditions
  • Products in Development
    • ABT-773
    • ACAM2000
    • Amoxicillin PULSYS
    • Anidulafungin
    • Aplaviroc
    • AzaSite
    • Aztreonam Lysinate
    • Buffer Gel
    • Ceftobiprole (BAL5788)
    • Cervarix
    • Cubicin (daptomycin for injection)
    • Dalbavancin
    • Doripenem
    • Extina
    • Faropenem daloxate
    • Gardasil
    • Garenoxacin
    • Helicide
    • Hyphanox
    • IFN-alpha Lozenge
    • Influvac TC
    • Iseganan
    • Interferon Alfacon/Ribaviron Combination
    • Macrotac
    • ME-609
    • Maraviroc
    • Multiferon
    • MX-226 (CPI-226)
    • Neuprex
    • Noxafil
    • Oracea
    • Oritavancin
    • PolyphenonE Ointment
    • PRO 2000
    • Ramoplanin
    • Retapamulin
    • Rotarix
    • SAVVY
    • Simplirix
    • SPO1A
    • StaphVAX
    • Streptorix
    • T-3811
    • Telavancin
    • Telbivudine
    • Tifacogin
    • Tolevamer
    • Tripranavir
    • Ushercell
    • Veronate
    • Viramidine
    • Zadaxin
  • Market Size and Growth
  • Competitive Analysis

Chapter Six: Cancer Drugs: Phase III Development Analysis

• Overview
  • Biochemistry of Cancer Cells
  • Carcinogen Metabolism
  • Causes of Cancer Growth
  • Environmental Factors, DNA, RNA
  • Cellular Oncogenes
  • Tumor Suppressor Genes
  • Types of Cancer
  • Bladder/Urinary Cancer
  • Breast Cancer
  • Cervical Cancer
  • Colorectal Cancer
  • Endometrial (Uterine) Cancer
  • Esophageal Cancer
  • Head and Neck
  • Kidney
  • Leukemia
  • Liver
  • Lung Cancer
  • Lymphoma
  • Melanoma
  • Multiple Myeloma
  • Neuroblastoma
  • Ovarian Cancer
  • Pancreatic Cancer
  • Prostate Cancer
  • Stomach Cancer
  • Incidence of Conditions
  • Products in Development
    • Acapodene
    • Advexin
    • Allovectin-7
    • Alvocidib
    • AMD-3100 (Mozobil)
    • Arzoxifene
    • Atamestane
    • Avastin
    • Avicine
    • Biovaxid
    • Canvaxin
    • Ceplene
    • Cintredekin besudotox (IL13-PE38)
    • Cloretazine
    • CoFactor
    • Cotara
    • DCVAX -Prostate
    • Doxil
    • DTI 015
    • Edotecarin
    • Efaproxyn
    • FavId
    • Genasense
    • Glufosfamide
    • GMK Therapeutics Vaccine
    • GVAX Prostate
    • HuMax CD4
    • IGN101
    • Insegia
    • Ixabepilone
    • Javlor
    • Junovan
    • Lapatinib
    • Lasofoxifene
    • MDX-010
    • MyVax
    • Neovastat
    • Nexavar (previously BAY 43-9006) (Sorafinib)
    • NOV-022
    • Onconase
    • Oncophage
    • OncoVax
    • Orathecin
    • OvaRex
    • Panitumumab
    • Panvac-VF
    • Rencarex
    • Satraplatin
    • Sipuleucel-T (Provenge)
    • STR
    • Tavocept
    • Taxoprexin
    • Telcyta
    • Temsirolimus
    • TheraCIMhR3(Nimotuzunab)
    • Thymitaq
    • TransMID-R
    • Vatalanib
    • Vinorelbine IV
    • Xcytrin
    • Xerecept
    • XL119
    • Xorane
    • XRP9881
    • Xyotax
    • Yondelis
    • Zactima
    • Zarnestra
    • ZYC101a
  • Market Size and Growth
  • Competitive Analysis

Chapter Seven: Other Drugs: Phase III Development Analysis

• Overview
• Conditions
  • Types of Conditions, Diseases and Disorders
  • Diabetes
  • Irritable Bowel Syndrome /Crohn's Disease
  • Psoriasis
  • Rheumatoid Arthritis
  • Osteoporosis
  • COPD/Asthma
  • Incidence of Conditions
  • Products in Development
    • 406381
    • Aclasta
    • Acomplia
    • AERx iDMS
    • Alicaforsen
    • Alista
    • Allermist
    • Alprox TD
    • Alvesco
    • ALX-0600
    • AMG 162 (Denosumab)
    • Aridol
    • Arxxant
    • Arformoterol
    • Asoprisnil
    • Axokine
    • Bazedoxifene
    • Belatacept
    • Bio-E-Gel
    • Biopten
    • Bronchitol
    • CDP 870
    • Ceprotin
    • Chrysalin
    • Cilansetron
    • Cimzia
    • Cordase
    • CS-917
    • Dapoxetine
    • Daxas
    • DE-085
    • Dexloxiglumide
    • DPP4 Inhibitor Oral(Saxasliptin)
    • E2/DNG Pill
    • Eculizumab
    • Evamist
    • Exanatide
    • Exubera
    • FC Patch
    • Ferumoxytol
    • Fersterodine
    • FIBRILLEX
    • Formoterol HFA ( Fordil Certihaler)
    • Fortigel
    • Galida
    • Human Growth Hormone
    • ICA-17043
    • IoGen
    • ISV-205
    • Itax
    • LAF237
    • Lasofoxifene (Oporia)
    • LEA29Y
    • LibiGel
    • Librel
    • Livial
    • Lucentis
    • Menopausal Levonorgestrel System
    • Mepolizumab
    • Methylnaltrexone
    • MK-0431(Sitagliptin)
    • Muraglitazar (Pargluva)
    • NovoMix 50 and 70
    • Onercept
    • OPC-6535
    • Oral Calcitonin
    • OrBec
    • Oxygent
    • Pennsaid Topical Solution
    • Phenoptin
    • PhotoPoint
    • PHP
    • Posurdex
    • PREOS
    • Prexige
    • Primolux
    • PTI-901
    • QAB149
    • Rebamipide
    • ReFacto AF
    • Retanne
    • SPD 476
    • SPI-0211/RU0211 (Lubiprostone)
    • SR 121463
    • Stannsoporfin (Stanate)
    • Starlix and Diovan
    • Tanaproget
    • Teduglutide
    • Terlipressin
    • Tolevamer
    • Tostrelle
    • VP002
    • XP12B
    • YAZ
    • Zelnorm
  • Market Size and Growth
  • Competitive Analysis