Blood: The Worldwide Market for Blood Products, Blood Testing, Blood Equipment, and Synthetic Blood Products

Table of Contents

Chapter One: Executive Summary

• Blood Collection
• Blood Typing and Testing for Diseases
  • Blood Typing
  • Blood Testing
• Blood Storage And Processing
• Blood Transfusions
• Blood Management And Safety Issues
• Synthetic Blood Products
• Scope And Methodology
• Blood Products Market
• Blood Testing And Typing Products Market
• Plasma and Blood Collection Equipment Market
• Synthetic Blood Products Market

Chapter Two: Introduction and Overview

• The Global Blood Industry
• History of the Blood Industry
  • United States
  • Europe
  • Asia
• Blood and its Components
  • Red Blood Cells (Erythrocytes)
  • White Blood Cells (Leukocytes)
  • Platelets
  • Plasma
• Immunoglobulin Products
• Blood Transfusions
  • Diseases Contracted from Blood Transfusions and Related Identification Testing
  • Transfusion-Associated Risks
• Efforts to Create a Virus-Free Blood Supply
  • Plasma Treatment
  • Platelet Treatments
• Synthetic Blood Products
  • Blood Volume Expanders
  • Hemoglobin Based Oxygen Carriers
  • Immunologic Properties
  • Vasoactive Properties
  • Performance
  • Perflurocarbon (PFC) Based Blood Products
  • Developmental Status
  • Commercialization Challenges
  • Factor Products for Hemophilia A
  • Synthetic Platelets

Chapter Three: The Blood Management System: Collection, Processing, and Use

• Blood Collection
• Organizations Collecting Blood
  • Not-For-Profit Blood Collection
  • Red Cross
  • Community Blood Banks
  • Hospitals
  • Other Blood Collection Sites
  • For-Profit Blood Collection
  • National Donor Deferral Registry
• Donor Donation Demographics
• Donor Recruitment
• Blood Screening and Evaluation
• Methods for Collecting Blood from Donors
  • Manual Blood Collection
  • Automated Blood Collection
  • Plasmapheresis
  • Plateletpheresis
  • Leukopheresis
  • Red Blood Cell Apheresis
• Cord Blood Collection
• Plasma Collection
  • Plasma Fractionators
  • Distributors/Brokers
• Blood Typing and Testing for Diseases
  • Blood Typing
  • Methods of Blood Typing
  • Manual Blood Typing Methods
  • Automated Blood Typing and Screening Methods
• Blood Testing
  • Nucleic Acid Amplification Testing (NAT)
  • CBER Licensed NAT Screening Tests
  • Polymerase Chain Reaction (PCR) Amplification
  • CBER Licensed PCR Screening Tests
  • Immunoassays
  • Enzyme-Linked Immunosorbent Assays
  • Basic ELISA
  • Alternate ELISA Methods
  • Sandwich Method
  • Reverse Sandwich Method
  • Reverse Sandwich Inhibition Method
  • Costs and Other Barriers
  • Blood Storage
• Blood Processing
  • Cohn Fractionation
  • Classical Fractionation Methods
  • Advanced Fractionation Methods
  • Cascade Plasma Fractionation
• Blood Transfusions
  • Testing Before Transfusion
  • Coombs Test
  • Manual Cross-Match Techniques
  • Major Cross-Match
  • Minor Cross-Match
  • Antibody Screen
• Types of Transfusions
  • Packed Red Blood Cells
  • Platelets
  • Leukocytes
  • Fresh Frozen Plasma (FFP)
  • Cryoprecipitate
  • Immune Serum Globulin/IMIG/IGIV
  • FactorVIII
  • Factor IX and Factor IX Complex
  • Factor VIIa
  • Fibrin/Thrombin
  • Therapeutic Apheresis
• Blood Management Issues
  • Availability
  • Increasing Repeat Donation Rates
  • Increasing Voluntary Donation
  • Safety Issues
  • Reducing Blood Typing Errors
  • Improving Donor Screening
  • Improving Viral Screening
  • Enhancing Viral Inactivation Processes
  • Preventing Bacterial Infections
  • Prion Reduction
  • Other Safety Precautions

Chapter four: The Human Blood and Blood Products Market

• Driving Forces of the Human Blood Industry
  • Variables Influencing the Demand for Blood Transfusions
  • Market Size
• Changing Patterns of Transfusion Procedures
  • Leukocyte Reduction
  • Impact of Autologous Donations
  • Types of Autologous Donations
• Pricing of Blood
  • National Blood Exchange
  • RBCs and Leukoreduced RBCs
  • Washed Red Blood Cells
  • Deglycerolized Red Blood Cells
  • Single-Donor Platelets and Random-Donor Platelets
  • Fresh Frozen Plasma and Platelet-Rich Plasma
  • Cryoprecipitate
  • Granulocytes
  • Gamma-Irradiated Blood
• Average Cost of Transfusion
• Plasma and Plasma Derived Products
  • Plasma Market Size
  • Market Dynamics
  • Immunoglobulins
  • Immunoglobulin Market Dynamics
  • Immunoglobulin Market Size
  • RSV Immunoglobulin
  • CMV Immunoglobulin
  • Hepatitis B Immunoglobulin
  • RhoD Immunoglobulin
  • Tetanus Immunoglobulin
  • Rabies Immunoglobulin
  • Varicella Immunoglobulin
  • Vaccinia Immunoglobulin
  • Albumin
  • Albumin Market Dynamics
  • Albumin Market Size
  • Prothrombin Complex Concentrates
  • Alpha-1 Proteinase Inhibitors
  • Fibrin Sealants
  • Clotting Factors and Factor VIIa

Chapter five: The Blood Testing and Typing Markets

• Blood Testing Products for Donor Screening
  • Market Size
  • Immunoassays
  • Nucleic Acid Testing
  • Market Participants
  • Immunoassays
  • Nucleic Acid Testing
• Blood Typing Products
• Plasma and Blood Collection Equipment
  • Market Participants

Chapter six: Synthetic Blood Products Market

• Driving Forces of the Synthetic Blood Products Industry
• Recombinant Factor Market
  • Market Size
• Oxygen Carrier Market
• Synthetic Blood Products in Clinical Development
  • Hemolink (Hemosol)
  • Hemopure (Biopure)
  • PolyHeme (Northfield Laboratories)
  • Oxygent (Alliance Pharmaceutical)
  • Albrec (Mitsubishi Pharma)
  • PHP (Curacyte)
  • Advate (Baxter)
• Recombinant Factors
  • Synthocytes
  • Gene Therapy
• Other Research Initiatives
  • Jerome H. Holland Laboratory
  • Center for Blood Research
  • National Blood Foundation

Chapter seven: Company Profiles

• Abbott Laboratories
• Alliance Pharmaceuticals
• American Association of Blood Banks (AABB)
• America's Blood Centers
• American Red Cross
• Baxter International
• Biopure Corp.
• Bio-Rad Laboratories
• BioTime Inc.
• Chiron (Acquired by Novartis)
• Gen-Probe Inc.
• Grifols Biologicals, Inc.
• Haemonetics, Inc.
• Hemosol Corp.
• JP Laboratories Inc.
• Massachusetts Public Health Biologic Labs
• Medimmune Corp.
• Northfield Laboratories
• Novo Nordisk A/S
• Ortho Clinical Diagnostics
• Perftoran
• Sanguine Corp.
• Synthetic Blood International
• Talecris Biotherapeutics
• ZLB Behring

List of Exhibits

Chapter One: Executive Summary

• Exhibit 1: Market Summary: Global Blood Products Market by Component 2005
• Exhibit 2: Global Projected Blood Banking and Plasmapheresis Molecular Diagnostics Testing Market Estimates by Analyte 2005-2012
• Exhibit 3: Global Market for Blood Collection Equipment Total Revenue vs Automated Equipment Revenue 2000-2012
• Exhibit 4: Recombinant Factor and High Blood Loss Market 2005-2012

Chapter Two: Introduction and Overview

• Exhibit 5: Timeline of Global Blood Industry Development 2006-2011
• Exhibit 6: Composition of Blood Plasma
• Exhibit 7: Viral Inactivation Methods for Viruses Found in Platelets
• Exhibit 8: Viral Inactivation Methods for Viruses Found in Red Blood Cells

Chapter Three: The Blood Management System: Collection, Processing, and Use

• Exhibit 9: Worldwide Annual Blood Collection by Component
• Exhibit 10: Basic Blood Types
• Exhibit 11: Blood Transfusion Compatibility
• Exhibit 12: PCR-Based Screening Tests Licensed by CBER
• Exhibit 13: Comparison of Direct and Indirect ELISA
• Exhibit 14: Results of Cohn Fractionation Method
• Exhibit 15: Plasma Proteins of Therapeutic Interest
• Exhibit 16: Risk of Contamination by Organism/Contaminant
• Exhibit 17: Viral Inactivation by Procedures and Targets

Chapter four: The Human Blood and Blood Products Market

• Exhibit 18: Geographical Distribution of RBC Demand by Region (United States, Europe, Japan, ROW) 2005
• Exhibit 19: Projected World Demand for RBCs 2005-2012
• Exhibit 20: Worldwide Demand for RBCs for Acute and Chronic Conditions, 2005
• Exhibit 21: Number of High Blood Loss Surgical Procedures, Units of RBC per Procedure, Total Units Transfused, and Total Market Value by Procedure Type (Gastrointestinal, Cardiovascular, Orthopedic, Urologic, Thoracic, Other) 2005
• Exhibit 22: Average Blood and Component Requirements by Condition
• Exhibit 23: Global Blood Products Market by Type of Product, Number of Units, Average Price, and Total Value, 2005
• Exhibit 24: Global Blood Collection and Transfusion Estimates (Millions of Units) 2005-2012
• Exhibit 25: Global Plasma Collection and Transfusion Estimates 2005-2012
• Exhibit 26: Countries Conducting Routine Leukocyte Reduction, 2006
• Exhibit 27: Surgical Procedures Amenable to Autologous Blood Donation
• Exhibit 28: CMS Platelet Reimbursement Rates by CPT/HCPCS Code 2005
• Exhibit 29: CMS Platelet Reimbursement Rates, 2005
• Exhibit 30: Selected Plasma Derived Product Approvals (Year, Product, Manufacturer, Indication, Benefit) 2002-2006
• Exhibit 31: The Global Market for Plasma and Plasma Derived Products 2000-2012
• Exhibit 32: Selected Plasma Industry Shifts, 2003-2006
• Exhibit 33: Sales and Market Shares of Leading Suppliers of Plasma and Plasma Derived Products 2005
• Exhibit 34: Global Market for Immunoglobulins by Leading Manufacturer 2005-2012
• Exhibit 35: Global Market for Human Albumin Products by Brand 2005-2012
• Exhibit 36: Prevalence of Conditions Requiring Prothrombin Complex Concentrates by Factor
• Exhibit 37: Leading Factor IX Products, 2006

Chapter five: The Blood Testing and Typing Markets

• Exhibit 38: Global Blood Banking and Plasmapheresis Testing Volume by Molecular Diagnostics by Analyte (HIV, HCV, HBV, HAV, HTLV, WNV, Others) 2005-2012
• Exhibit 39: U.S. Blood Banking and Plasmapheresis Testing Volume by Molecular Diagnostics by Analyte (HIV, HCV, HBV, HAV, HTLV, WNV, Others) 2005-2012
• Exhibit 40: Global Projected Blood Banking and Plasmapheresis Molecular Diagnostics Testing Market Potential (Number of Tests, Cost per Test, Market Size) by Analyte (HIV, HCV, HBV, HAV, HTLV, WNV, Others) 2005-2012
• Exhibit 41: Projected Blood Banking and Plasmapheresis Molecular Diagnostics Testing Market Potential in the United States: 2005-2012
• Exhibit 42: Commercially Available Molecular (Nucleic Acid) Tests for Blood, Plasma and Organ Donor Screening in the United States (Tradename, Format, Sample, Use, Manufacturer, Approval Date)
• Exhibit 43: Global Market for Blood Collection Equipment 2005-2012
• Exhibit 44: Global Market for Automated Blood Collection Equipment: 2005-2012

Chapter six: Synthetic Blood Products Market

• Exhibit 45: World Recombinant Factor Market by Brand 2005-2012
• Exhibit 46: High Blood Loss Market HBOC and PFC Agent Revenues 2007-2012
• Exhibit 47: Recombinant Factor Products in Clinical Trials