Cell Culture: The World Market for Media, Sera, and Reagents

Table of Contents

Chapter One: Executive Summary

• Scope and Methodology
• Cells for Biopharmaceutical Production
  • Bacteria and Yeasts Systems
  • Animal Cell Systems
  • Insect Cell Systems
• Cell Lines and Cell Banks
• Fermentors and Bioreactors
  • Stirred-Tank Reactors
  • Airlift Fermentors
  • Packed Bed Reactors
  • Hollow-Fiber Reactor
  • Disposable Systems
• Fermentation Processes
  • Batch and Fed-Batch Fermentation
  • Suspended vs. Anchored Cells
  • Microencapsulation
• Cell Culture Environment: Functions and Components of Basal Media
  • pH and Osmotic Pressure
  • Energy Sources
  • Nutrients
• Cell Culture Media
  • Lysogeny broth (LB)
  • Classical Media
  • Serum-Free Media
  • Protein-Free Media
  • Chemically Defined Media
  • Specialty Media
• Sera
• Reagents
  • Shifting Towards Non-Animal Derived Reagents
  • Addressing Reagent Safety Issues
• World Cell Culture Market
  • Impact of Shift to Serum-free Products on Cell Culture Suppliers
  • Impact of Shift to Serum-Free Products On Research
  • Impact of Shift to Serum-Free Products on Biopharmaceutical Manufacturers
  • Market Drivers
• Cell Culture Market Forecast
• Trends Impacting The Cell Culture Market

Chapter Two: Genetically Modified Cells for Biopharmaceutical Development

• Overview
  • Growing Demand for Biopharmaceuticals
  • Demand Increasing for Cell Culture Products
  • A Brief History of Biotechnology
  • Science of Genetic Manipulation
• From Petri Dish to Biopharmaceutical
  • Upstream Bioprocessing: Cell Culture Expression Systems
  • Cells for Biopharmaceutical Production
    • Bacteria and Yeasts Systems
    • Animal Cell Systems
    • Insect Cell Systems
    • Advantages/Disadvantages of Cell Culture Systems
    • Cell Lines and Cell Banks
    • Biopharmaceuticals Produced from Cell Culture
  • Cell Culture Practices and Regulatory Guidelines
    • Validation of Facilities
    • Maintaining Sterilization Standards

Chapter Three: Cell Culture Technology

• Introduction and Overview
• Cell Lines for Bioproduction
  • Predominant Cell Lines
    • Chinese Hamster Ovary (CHO)
    • SP2/0, and NS0
    • HEK 293 and PER. C6
    • Sources: Largest Collections of Cell Lines
      • The European Collection of Cell Cultures (ECACC)
      • The American Type Cell Culture (ATCC)
    • Fermentors and Bioreactors
      • Types of Bioreactors/Fermentors
        • Stirred-Tank Reactors
        • Airlift Fermentors
        • Packed Bed Reactors
        • Hollow-fiber Reactor
        • Disposable Systems
      • Fermentation Processes
        • Batch and Fed-Batch Fermentation
        • Suspended vs. Anchored Cells
        • Microencapsulation
    • Cell Culture Environment:
      • pH and Osmotic Pressure
      • Energy Sources
      • Nutrients
    • Cell Culture Media
      • Lysogeny Broth (LB)
      • Classical Media
      • Serum-Free Media
      • Protein-Free Media
      • Chemically Defined Media
      • Specialty Media
    • Sera
      • Sources of Sera
      • Bovine Serum Safety Issues and Regulations
      • Shift to Serum-Free Media
    • Reagents
      • Major Types of Biologic Reagents
        • Amino Acids
        • Growth Factors and Cytokines
        • Albumin
        • Transferrin
        • Thrombin
        • Growth Supplements
        • Protease Inhibitor
        • Attachment Factors
      • Shifting Towards Non-animal Derived Reagents
      • Addressing Reagent Safety Issues

Chapter Four: Trends and Market Analysis

• Shift Away From Serum-Based Cell Culture
  • Impact of Shift to Serum-Free Products on Cell Culture Suppliers
  • Impact of Shift to Serum-Free Products on Research
  • Impact of Shift Serum-Free Products on Biopharmaceutical Manufacturers
• Cell Culture Market
  • Market Drivers
  • Cell Culture Market and Forecast
  • Segment Analysis
    • Media
    • Sera
    • Reagents
  • Market Characteristics
    • Major Acquisitions
  • Competitive Market Share
• Trends Impacting The Cell Culture Market
  • Stem Cell Research
    • Invitrogen
    • Sigma-Aldrich
    • Millipore Corporation
  • Cell Culture-Based Vaccine Production
  • Transgenically Produced Biopharmaceuticals

Chapter Five: Company Profiles

• Advanced Biotechnologies, Inc.
  • History and Lines of Business
  • Cell Culture Products and Services
• AMRESCO, Inc.
  • History and Lines of Business
  • Cell Culture Products
• Analytical Biological Services Inc.
  • History and Lines of Business
  • Cell Culture Products
    • Mammalian Cell Culture
    • Cell in Microtiter Plates for HTS
    • Primary Cultures
    • Insect Cell Culture
• Atlanta Biologicals, Inc.
  • History and Lines of Business
  • Cell Culture Products
• Athena Enzyme Services
  • History and Lines of Buiness
  • Cell Culture Products
• Biochrom AG
  • History and Lines of Business
  • Cell Culture Products
• BD Biosciences
  • History and Lines of Business
  • Cell Culture Products
  • Clinical and Clinical Research Reagents, which include:
    • Research Reagents, which include:
  • Financial Information
• Cambrex Corporation
  • History and Lines of Business
  • Cell Culture Products
  • Financial Information
• Cell Essentials, Inc.
  • History and Lines of Business
  • Cell Culture Products
• CellGenix Technologie Transfer GmbH
  • History and Lines of Business
  • Cell Culture Products and Services
• Fisher Scientific International, Inc.
  • History and Lines of Business
  • Cell Culture Products
  • Financial Information
• Invitrogen Corporation
  • History and Lines of Business
  • Cell Culture Products
  • Financial Information
• Irvine Scientific
  • History and Lines of Business
  • Cell Culture Products
• J R Scientific, Inc.
  • History and Development
  • Cell Culture Products
• Hyclone Laboratories
  • History and Lines of Business
  • Cell Culture Products
• Kemp Biotechnologies, Inc.
  • History and Lines of Business
  • Cell Culture Products
    • Cell Culture - Fermentation
    • Cell Culture - Stable Mammalian
    • Cell Culture - Mammalian Transient Transfection
    • Cell Culture - Baculovirus (Insect Cell)
• Mediatech, Inc.
  • History and Lines of Business
  • Cell Culture Products
• Millipore Corporation
  • History and Lines of Business
  • Cell Culture Products
  • Financial Information
• PAA Laboratories, Inc.
  • History and Lines of Business
  • Cell Culture Products
• PromoCell GmbH
  • History and Lines of Business
  • Cell Culture Products
• Quality Biological, Inc.
  • History and Lines of Business
  • Cell Culture Products
• R&D Systems, Inc.
  • History and Lines of Business
  • Cell Culture Products
• SBH Sciences
  • History and Lines of Business
  • Cell Culture Products
• Selexis SA
  • History and Lines of Business
  • Cell Culture Products
• SeraCare Life Sciences, Inc.
  • History and Lines of Business
  • Cell Culture Products
• Sigma-Aldrich Corporation
  • History and Lines of Business
  • Cell Culture Products
  • Financial Information
• USB Corporation
  • History and Lines of Business
  • Cell Culture Products
• Wisent, Inc.
  • History and Lines of Business
  • Cell Culture Products
• Appendix: Company Directory

List of Exhibits

Chapter One: Executive Summary

• Exhibit 1-1: Market Summary: World Cell Culture Market 2002-2011

Chapter Two: Genetically Modified Cells for Biopharmaceutical Development

• Exhibit 2-1: Biopharmaceuticals Appoved in the US or the EU in 2005 (Product, Expression, Indications, Company)
• Exhibit 2-2: Approximate Times from Introduced Gene to Protein Production at Useable Levels by Expression System (Bacteria, Yeast, Mammilian, Insect)
• Exhibit 2-3: Disadvantages/Advantages of Cell Culture Systems by Expression System (Bacteria, Yeast, Animal, Insect)
• Exhibit 2-4: Selected Biopharmaceuticals Produced from Bacteria, Yeast and Mammalian Cells (Expression System, Product, Manufacturer, Indication)

Chapter Three: Cell Culture Technology

• Exhibit 2-1: Selected Products/Companies Offering Alternatives to Animal Sera Products for Hybridoma, Myeloma, and CHO cell lines (Company, Product, Type ADCF, CD, CSFM, PF, SF, SFM, Cell Line)

Chapter Four: Trends and Market Analysis

• Exhibit 4-1: Selected Brand Name Serum-Free Formulations of Cell Culture Products Currently on the Market (Brand, Product, Manufactuer)
• Exhibit 4-2: World Cell Culture Market Revenues and Growth 2002-2011
• Exhibit 4-3: Cell Culture World Market Share by Geographical Region 2006
• Exhibit 4-4: Estimated Share of Cell Culture Media Market by Media Type (Animal Sourced vs Animal Free and Animal Free vs Chemically Defined)
• Exhibit 4-5: World Cell Culture Market Revenues by Segment (Media, Sera, Reagents) 2002-2011
• Table 4-6: Major Acquisitions in the Cell Culture Industry 2003-2006
• Exhibit 4-7: Cell Culture Revenues and Market Share by Leading Competitor 2005