Anti Infectives, Vol II: Antibacterials

Table of Contents

Executive Summary

• Introduction
• Scope and Methodology
• Size and Growth of the Market
• Issues and Trends Affecting Market
• Leading Competitors

Introduction The World Market for Anti-Infectives Volume 2:

• Antibacterial Drugs
• Introduction to pathogens
  • Classification of Antibacterial Organisms
  • Antimicrobial Spectrum
  • Bacterial Resistance
  • Principles of Anti-infective Therapy
  • Infecting Organism
  • Antibiotic Sensitivity Testing
  • Site of Infection
  • Host Defenses and Organ Function
  • Antibiotic Pharmacokinetics
  • Monitoring Therapy
  • Combination Therapy and Prophylactic Use
• Demographics and Statistics

Issues and Trends Affecting the Antibacterial Drug Market

• introduction
• Drug Resistance and Interactions
• Antibiotic Abuse
• Antibiotic Cycling
• addressing market trends
• Antibiotic use in Agriculture
• Antibiotic Education
• Children and Bacterial resistance
• The Elderly and Bacterial Resistance
• Compromised Individuals and Bacterial Resistance
• Screening Hospitalized patients
• Side Effects of Antibiotics
• Partnerships and Alliances
• Environment and Drug Resistance
• Methicillin-resistant Staphylococcus Aureus (MRSA)

Cephalosporin Antibiotics

• Overview
• Description of Products
  • First Generation Cephalosporins
  • Cephalexin (Keflex, Advancis Pharmaceuticals)
  • Cefazolin (Ancef, GlaxoSmithKline; Cefamezin, Astellas)
  • Cefadroxil (Duricef, Bristol-Myers Squibb/Warner Chilcot)
  • Second Generation Cephalosporins
  • Cefuroxime (Ceftin, GlaxoSmithKline)
  • Cefoxitin (Mefoxin, Merck)
  • Third Generation Cephalosporins
  • Cefotaximen (Claforan offered by Sanofi-Aventis)
  • Cefoperazone (Cefobid, Pfizer)
  • Ceftibutin (Cedax, Shionogi)
  • Ceftizoxime (Cefizox, Astellas)
  • Ceftriaxone (Rocephin, Roche)
  • Ceftazidime (Fortaz, GlaxoSmithKline)
  • Cefixime (Suprax, Wyeth/Lupin Pharmaceuticals)
  • Cefpodoxime (Vantin, Pfizer)
  • Fourth Generation Cephalosporins
  • Cefepime (Maxipime, Bristol-Myers Squibb)
• Generic Drug Impact and Availability
• Research and Development
• Market Size and Growth
• Competitive Analysis

Macrolide Antibiotics

• Overview
• Description of Products
  • Azithromycin (Zithromax, Pfizer; Zmax, Pfizer)
  • Clarithromycin (Biaxin, Abbott Laboratories)
  • Erythromycin (Erythrocin, Abbott Laboratories; EryPed, Abbott Laboratories)
  • Telithromycin (Ketek, Sanofi-Aventis)
• Generic Drug Impact and Availability
• Research and Development
• Market Size and Growth
• Competitive Analysis

Penicillin Antibiotics

• Overview
• Natural Penicillins
• Penicillinase-Resistant Penicillins
• Broad -Spectrum Penicillins
• Extended-Spectrum Penicillins

Description of Products

• Natural Penicillins
• Penicillin G (Bicillin, King Pharmaceuticals; Pfizerpen, Pfizer)
• Penicillinase-resistant Penicillins
• Cloxacillin (Cloxapen, GlaxoSmithKline)
• Oxacillin (Bactocill, GlaxoSmithKline)
• Broad-spectrum Penicillins
• Amoxicillin (Augmentin, GlaxoSmithKline; Amoxil,GlaxoSmithKline)
• Ampicillin (Unasyn, Pfizer)
• Extended-spectrum Penicillins
• Carbenicillin (Geocillin, Pfizer)
• Piperacillin (Pipracil, Wyeth; Zosyn, Wyeth)
• Ticarcillin (Timentin, GlaxoSmithKline)

• Generic Drug Impact and Availability
• Research and Development
• Market Size and Growth
• Competitive Analysis

Quinolone Antibiotics

• Overview
• Description of Products
  • Ciprofloxacin (Cipro, Bayer; Proquin XR, Depomed)
  • Gemifloxacin (Factive, LG Chem Ltd. and Oscient Pharmaceuticals)
  • Lomefloxacin (Maxaquin, Unimed)
  • Nalidixic (NegGram, Sanofi-Aventis)
  • Norfloxacin (Noroxin, Merck)
  • Ofloxacin (Floxin, Ortho-McNeil)
  • Moxifloxicin (Avelox, Bayer; Vigamox, Alcon)
  • Levofloxacin (Levaquin, Ortho-McNeil; Tavanic, Sanofi-Aventis; Cravit, Daiichi Sankyo; Quixin, Santen)
  • Gatifloxacin (Zymar, Allergan/Kyorin)
  • Trovafloxacin (Trovan, Pfizer)
• Generic Drug Impact and Availability
• Research and Development
• Market Size and Growth
• Competitive Analysis

Sulfonamide Antibiotics

• Overview
• Description of Products
• Sulfisoxazole (Gantrisin Pediatric, Roche)
  • Oxytetracycline/Sulfamethizole/Phenazopyridine (Urobiotic, Pfizer)
  • Erythromycin ethylsuccinate and Sulfisoxazole acetyl (Pediazole, Ross)
  • Dapsone (Aczone Gel, QLT USA-Tolmar Inc.)
• Research and Development
• Market Size and Growth
• Competitive Analysis

Tetracycline Antibiotics

• Overview
• Description of Products
• Generic Drug Impact and Availability
• Research and Development
• Market Size and Growth
• Competitive Analysis

Other Miscellaneous Antibiotics

• Overview
• Description of Products
• Aminoglycosides
  • Amikacin Sulfate (Amikin, Bristol-Myers Squibb)
  • Kanamycin Sulfate (Kantrex, Bristol-Myers Squibb)
  • Neomycin Sulfate (Neo-fradin, X Gen Pharms)
  • Streptomycin Sulfate (Streptomycin, Pfizer)
  • Lincomycin
  • Clindamycin (Cleocin, Pfizer; Clindesse, KV Pharmaceutical Company; Evoclin, Connetics Corp.; Ziana Gel, Medicis/Dow)
  • Chloramphenicol
  • Chloramphenicol (Chloromycetin,Pfizer)
  • Glycopeptide
  • Vancomycin (Vancocin, Viropharma)
  • Monobactams
  • Aztreonam (Azactam, Bristol-Myers Squibb)
  • Carbapenems
  • Imipenem/cilastatin (Primaxin, Merck)
  • Meropenem (Merrem, AstraZeneca)
  • Metronidazole
  • Metronidazole (Flagyl, Pfizer; Pylera, Axcan; Metrogel-Vaginal, 3M Pharmaceuticals; MetroGel, Galderma)
  • Antituberculars
  • Rifampicin (Rifater, Sanofi-Aventis)
  • Capreomycin (Capastat sulfate, Eli Lilly & Co.)
  • Ethionamide (Trecator SC, Wyeth)
  • Aminosalicylic acid granules (Paser Granules, Jacobus Pharmaceutical)
  • Cycloserine (Seromycin, Eli Lilly & Co.)
  • Antileprotics
  • Dapsone (Dapsone, Jacobus)
  • Oxazolidinones
  • Linezolid (Zyvox, Pfizer)
  • Ketolides
  • Telithromycin (Ketek, Sanofi-Aventis)
  • Lipopeptides
  • Daptomycin (Cubicin, Cubist Pharmaceutical)
  • Glycyclines
  • Tigecycline (Tygacil, Wyeth)
  • Generic Drug Impact and Availability
  • Research and Development
  • Market Size and Growth
  • Competitive Analysis

Corporate Profiles

• Introduction
• Abbott Laboratories
• AstraZeneca plc
• Bayer Schering Pharma AG
• Cubist Pharmaceuticals, Inc
• Daiichi Sankyo Co., Ltd.
• GlaxoSmithKline
• Johnson & Johnson Group
• King Pharmaceuticals, Inc.
• Merck & Company, Inc.
• Pfizer, Inc.
• Roche
• Sanofi-Aventis
• Wyeth

Company Names and Addresses