US Markets for Orthopedic Biomaterials 2007

Table of Contents

TABLE OF CONTENTS

LIST OF EXHIBITS

EXECUTIVE SUMMARY

METHODOLOGY

1.0 ORTHOPEDIC BIOMATERIALS BACKGROUND

• 1.1 Bone Graft Overview
  • 1.1.1 Autograft
  • 1.1.2 Allograft
  • 1.1.3 Demineralized Bone Matrix
  • 1.1.4 Synthetic Bone
  • 1.1.5 Growth Factors
• 1.2 Hyaluronic Acid Viscosupplementation Overview
  • 1.2.1 Hyaluronic Acid Viscosupplementation Reimbursement
• 1.3 Osteoarthritis Overview
  • 1.3.1 Causal Factors
  • 1.3.2 Incidence
  • 1.3.3 Treatment Alternatives to Hyaluronic Acid Viscosupplementation
    • 1.3.3.1 Nonpharmacologic Treatments
    • 1.3.3.2 Pharmacologic Treatments
• 1.4 Machined Bone Interbody Devices Overview
• 1.5 Cartilage Repair Overview
  • 1.5.1 Osteoarticular Autografts
  • 1.5.2 Osteoarticular Allografts
  • 1.5.3 Autologous Chondrocyte Implantation
• 1.6 Platelet Concentration Systems Overview
• 1.7 Orthopedic Stem Cell Products Background

2.0 US ORTHOPEDIC BIOMATERIAL MARKET

• 2.1 Market Overview
• 2.2 Market Analysis
  • 2.2.1 Procedures
  • 2.2.2 Market Forecast
    • 2.2.2.1 Bone Graft Substitutes
    • 2.2.2.2 Hyaluronic Acid Viscosupplementation
    • 2.2.2.3 Machined Bone Interbody Device
    • 2.2.2.4 Cartilage Repair
    • 2.2.2.5 Platelet Concentration Systems
• 2.3 Competitive Analysis

3.0 BONE GRAFT SUBSTITUTES

• 3.1 Market Overview
• 3.2 Market Analysis
  • 3.2.1 Procedures
  • 3.2.2 Segmentation by Material
    • 3.2.2.1 Autograft
    • 3.2.2.2 NP Allograft
    • 3.2.2.3 Demineralized Bone Matrix
    • 3.2.2.4 Synthetic
    • 3.2.2.5 Growth Factors
  • 3.2.3 Segmentation by Application
  • 3.2.4 Market Forecast
• 3.3 Spinal Fusion Market Overview
  • 3.3.1 Thoracolumbar Fusion Market
  • 3.3.2 Cervical Fusion Market
• 3.4 Trauma Application Market Overview
  • 3.4.1 Fresh Fracture Market
  • 3.4.2 Nonunion Fracture Market
• 3.5 Reconstructive Surgery Market Overview
  • 3.5.1 Revision Hip Market
  • 3.5.2 Revision Knee Market
  • 3.5.3 Primary Knee Market
  • 3.5.4 Primary Hip Market
• 3.6 Craniomaxillofacial Market Overview
  • 3.6.1 Market Drivers and Limiters
    • 3.6.1.1 Market Drivers
    • 3.6.1.2 Market Limiters
• 3.7 Competitive Analysis
  • 3.7.1 Leading Competitors
• 3.8 Products in Development
  • 3.8.1 Small Peptides
    • 3.8.1.1 P-15
    • 3.8.1.2 Peptos
    • 3.8.1.3 Chrysalin
    • 3.8.1.4 B2A2
  • 3.8.2 GFs
    • 3.8.2.1 GEM OS
    • 3.8.2.2 LIM Mineralization Protein-1
    • 3.8.2.3 rhGDF-5 (formerly known as MP52)
    • 3.8.2.4 PuraMatrix
    • 3.8.2.5 BST-GEL
    • 3.8.2.6 Ossigel

4.0 HYALURONIC ACID VISCOSUPPLEMENTATION

• 4.1 Market Overview
• 4.2 Market Analysis
  • 4.2.1 Procedures
    • 4.2.1.1 Total Injection Volumes
    • 4.2.1.2 Total Treatment Volumes
  • 4.2.2 Indications
  • 4.2.3 Market Forecast
  • 4.2.4 Market Drivers and Limiters
    • 4.2.4.1 Market Drivers
    • 4.2.4.2 Market Limiters
• 4.3 Competitive Analysis
  • 4.3.1 Leading Competitors
  • 4.3.2 Emerging Competitors

5.0 MACHINED BONE INTERBODY DEVICES

• 5.1 Market Overview
• 5.2 Market Analysis
  • 5.2.1 Market Forecast
  • 5.2.2 Market Drivers and Limiters
    • 5.2.2.1 Market Drivers
    • 5.2.2.2 Market Limiters
• 5.3 Competitive Analysis

6.0 CARTILAGE REPAIR

• 6.1 Market Overview
• 6.2 Market Analysis
  • 6.2.1 Procedures
  • 6.2.2 Market Forecast
    • 6.2.2.1 ACI Market
    • 6.2.2.2 OA Allograft Market
  • 6.2.3 Market Drivers and Limiters
    • 6.2.3.1 Market Drivers
    • 6.2.3.2 Market Limiters
• 6.3 Competitive Analysis
  • 6.3.1 Leading Competitors
  • 6.3.2 Emerging Competitors
  • 6.3.3 Meniscal Cartilage Repair

7.0 PLATELET CONCENTRATION SYSTEMS

• 7.1 Market Overview
• 7.2 Market Analysis
  • 7.2.1 Market Forecast
  • 7.2.2 Market Drivers and Limiters
    • 7.2.2.1 Market Drivers
    • 7.2.2.2 Market Limiters
• 7.3 Competitive Analysis

8.0 ORTHOPEDIC STEM CELL PRODUCTS

• 8.1 Market Overview
• 8.2 Market Analysis
  • 8.2.1 Procedures
  • 8.2.2 Market Forecast
  • 8.2.3 Market Drivers and Limiters
    • 8.2.3.1 Market Drivers
    • 8.2.3.2 Market Limiters
• 8.3 Competitive Analysis
• 8.3.1 Emerging Competitors

APPENDIX A: MRG ACRONYMS AND INITIALISMS

List of Exhibits

EXECUTIVE SUMMARY

• Exhibit ES-1: Orthopedic Biomaterial Market, US (US$), 2005-2011
• Exhibit ES-2: BGS Market, by Application, US (US$), 2005-2011
• Exhibit ES-3: HA Treatment ASP, US (US$), 2005-2011
• Exhibit ES-4: Machined Bone IBD Market, by Approach, as a % of Total, US, 2011
• Exhibit ES-5: Cartilage Repair Market Growth, US (US$), 2006-2011
• Exhibit ES-7: OSCP Market, US (US$), 2005-2011
• Exhibit ES-8: Leading Competitors of the Orthopedic Biomaterial Market, US, 2006

CHAPTER 1: ORTHOPEDIC BIOMATERIALS BACKGROUND

• Exhibit 1-1: Characteristics of BGS Materials
• Exhibit 1-2: Advantages and Disadvantages of Various BGS Materials
• Exhibit 1-3: Selected Synthetic BGS Materials

CHAPTER 2: US ORTHOPEDIC BIOMATERIAL MARKET

• Exhibit 2-1: Orthopedic Biomaterial Market, by Segment, as a % of Total, US, 2006
• Exhibit 2-2: Orthopedic Biomaterial Market, by Device, US (US$), 2005-2011
• Exhibit 2-3: Leading Competitors in the US Orthopedic Biomaterial Market, by Device, 2006

CHAPTER 3: BONE GRAFT SUBSTITUTES

• Exhibit 3-1: US BGS Market (US$), 2005-201
• Exhibit 3-2: BGS Procedures, US, 2005-2011
• Exhibit 3-3: Bone Graft Procedures, by Material, US, 2005-2011
• Exhibit 3-4: BGS Procedures, by Material, as a % of Total, US, 2005-2011
• Exhibit 3-5: Average Amount of Bone Graft Material Used by Indication
• Exhibit 3-6: BGS Procedures, by Application, US, 2005-2011
• Exhibit 3-7: BGS Procedures, by Application, as a % of Total, US, 2005-2011
• Exhibit 3-8: BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-9: BGS Market, by Application, US (US$), 2005-2011
• Exhibit 3-10: Spine BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-11: Spine BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-12: Spine BGS Market, by Application, US (US$), 2005-2011
• Exhibit 3-13: Thoracolumbar Spine BGS Procedures, by Material, as a % of Total, US, 2005-2011
• Exhibit 3-14: Thoracolumbar Spine BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-15: One-Level Thoracolumbar Spine BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-16: Two-Level Thoracolumbar Spine BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-17: Multilevel Thoracolumbar Spine BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-18: Thoracolumbar Spine BGS ASPs, by Material, US (US$), 2005-2011
• Exhibit 3-19: One-Level Thoracolumbar Spine BGS ASPs by Material, US (US$), 2005-2011
• Exhibit 3-20: Two-Level Thoracolumbar Spine BGS ASPs, by Material, US (US$), 2005-2011
• Exhibit 3-21: Multilevel Thoracolumbar Spine BGS ASPs, by Material, US (US$), 2005-2011
• Exhibit 3-22: Thoracolumbar Spine BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-23: One-Level Thoracolumbar Spine BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-24: Two-Level Thoracolumbar Spine BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-25: Multilevel Thoracolumbar Spine BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-26: Cervical Fusion BGS Procedures, by Material, as a % of Total, US, 2005-2011
• Exhibit 3-27: Cervical Spine BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-28: One-Level Cervical Spine BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-29: Two-Level Cervical Spine BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-30: Multilevel Cervical Spine BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-31: Cervical Spine BGS ASPs, by Material, US (US$), 2005-2011
• Exhibit 3-32: One-Level Cervical Spine BGS ASPs, by Material, US (US$), 2005-2011
• Exhibit 3-33: Two-Level Cervical Spine BGS ASPs, by Material, US (US$), 2005-2011
• Exhibit 3-34: Multilevel Cervical Spine BGS ASPs, by Material, US (US$), 2005-2011
• Exhibit 3-35: Cervical Spine BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-36: One-Level Cervical Spine BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-37: Two-Level Cervical Spine BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-38: Multilevel Cervical Spine BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-39: Trauma BGS Procedures, by Material, as a % of Total, US, 2005-2011
• Exhibit 3-40: Trauma BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-41: Trauma BGS ASP, by Material, US (US$), 2005-2011
• Exhibit 3-42: Trauma BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-43: Fresh Fracture Procedures, by Type, US, 2005-2011
• Exhibit 3-44: Fresh Fracture Procedures Using BGS Material, US, 2005-2011
• Exhibit 3-45: Fresh Fracture BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-46: Fresh Fracture BGS ASPs, by Material, US (US$), 2005-2011
• Exhibit 3-47: Fresh Fracture BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-48: Nonunion Fracture Procedures Using BGS Material, US, 2005-2011
• Exhibit 3-49: Nonunion Fracture BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-50: Nonunion Fracture BGS ASPs, by Material, US (US$), 2005-2011
• Exhibit 3-51: Nonunion Fracture BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-52: Reconstructive BGS Procedures, by Indication, US, 2005-2011
• Exhibit 3-53: Reconstructive Surgery BGS Procedures, by Material, as a % of Total, 2005-2011
• Exhibit 3-54: Reconstructive BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-55: Revision Hip BGS Penetration, US, 2005-2011
• Exhibit 3-56: Revision Hip BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-57: Revision Hip BGS ASPs per Procedure, by Material, US (US$), 2005-2011
• Exhibit 3-58: Revision Hip BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-59: Revision Knee BGS Penetration, US, 2005-2011
• Exhibit 3-60: Revision Knee BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-61: Revision Knee BGS ASP per Procedure, by Material, US (US$), 2005-2011
• Exhibit 3-62: Revision Knee BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-63: Primary Knee BGS Penetration, US, 2005-2011
• Exhibit 3-64: Primary Knee BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-65: Primary Knee BGS ASPs per Procedure, by Material, US (US$), 2005-2011
• Exhibit 3-66: Primary Knee BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-67: Primary Hip BGS Penetration, US, 2005-2011
• Exhibit 3-68: Primary Hip BGS Procedures, by Material, US, 2005-2011
• Exhibit 3-69: Primary Hip BGS ASPs per Procedure, by Material, US (US$), 2005-2011
• Primary Hip BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-70: CMF BGS Procedures, by Material, as a % of Total, US, 2005-2011
• Exhibit 3-71: CMF BGS Procedures, by Material, 2005-2011
• Exhibit 3-72: CMF BGS ASPs per Procedure, by Material, US (US$), 2005-2011
• Exhibit 3-73: CMF BGS Market, by Material, US (US$), 2005-2011
• Exhibit 3-74: Drivers and Limiters of the BGS Market, US, 2006
• Exhibit 3-75: Leading Competitors in the BGS Market, by Segment, 2006

CHAPTER 4: HYALURONIC ACID VISCOSUPPLEMENTATION

• Exhibit 4-1: HA Viscosupplementation Market, US (US$), 2005-2011
• Exhibit 4-2: HA Injection and Treatment Volumes, US, 2005-2011
• Exhibit 4-3: HA Injection Volumes, by Indication, US, 2005-2011
• Exhibit 4-4: HA Treatment Volumes, by Indication, US, 2005-2011
• Exhibit 4-5: HA Injection Volumes, by Indication, as a % of Total, US, 2005-2011
• Exhibit 4-6: HA Treatment Volumes, by Indication, as a % of Total, US, 2005-2011
• Exhibit 4-7: HA Injection Market, US (US$), 2005-2011
• Exhibit 4-8: HA Treatment Market, by Indication, US (US$), 2005-2011
• Exhibit 4-9: Drivers and Limiters of the HA Viscosupplementation Market, US
• Exhibit 4-10: Leading Competitors in the HA Viscosupplementation Market, US, 2006

CHAPTER 5: MACHINED BONE INTERBODY DEVICES

• Exhibit 5-1: Machined Bone IBD Market, US (US$), 2005-2011
• Exhibit 5-2: Machined Bone IBD Market, by Approach, US (US$), 2006
• Exhibit 5-3: Machined Bone IBD Market, by Approach, US (US$), 2005-2011
• Exhibit 5-4: Machined Bone IBD Market Growth, by Approach, US, 2006-2011
• Exhibit 5-5: Machined Bone Devices per Procedure, US, 2005-2011
• Exhibit 5-6: Drivers and Limiters of the Machined Bone IBD Market, US
• Exhibit 5-7: Over-65 Cohort, US, 2000-2050
• Exhibit 5-8: Leading Competitors of the Machined Bone IBD Market, US, 2006

CHAPTER 6: CARTILAGE REPAIR

• Exhibit 6-1: Cartilage Repair Market, US (US$), 2005-2011
• Exhibit 6-2: Cartilage Repair Market, by Segment, US (US$), 2005-2011
• Exhibit 6-3: ACI Market, US (US$), 2005-2011
• Exhibit 6-4: OA Allograft Market, US (US$), 2005-2011
• Exhibit 6-5: Drivers and Limiters of the Cartilage Repair Market, US
• Exhibit 6-6: Leading Competitors in the Cartilage Repair Market, by Segment, US, 2006

CHAPTER 7: PLATELET CONCENTRATION SYSTEMS

• Exhibit 7-1: PCS Market, US (US$), 2005-2011 (Graphical Format)
• Exhibit 7-2: PCS Market, US (US$) 2005-2011 (Tabular Format)
• Exhibit 7-3: PCS Units, by Indication, US, 2005-2011
• Exhibit 7-4: Drivers and Limiters of the PCS Market, US
• Exhibit 7-5: Leading Competitors in the PCS Market, US, 2006

CHAPTER 8: ORTHOPEDIC STEM CELL PRODUCTS

• Exhibit 8-1: Orthopedic Stem Cell Products Market, US (US$) 2005-2011 (Graphical Format)
• Exhibit 8-2: Orthopedic Stem Cell Products Market, US (US$) 2005-2011 (Tabular Format)
• Exhibit 8-3: Drivers and Limiters of the OSC Product Market, US
• Exhibit 8-4: Leading Competitors of the OCSP Market, US, 2006