European Markets for Minimally Invasive Spinal Fusion Technologies 2007

Table of Contents

TABLE OF CONTENTS

LIST OF EXHIBITS

METHODOLOGY

EXECUTIVE SUMMARY

1.0 MINIMALLY INVASIVE SPINAL FUSION DEVICE OVERVIEW

• 1.1 Anatomy of the Human Spine
• 1.2 Degenerative Spinal Disorders
  • 1.2.1 Deformity Spinal Disorders
  • 1.2.2 Trauma/Tumor Spinal Disorders
  • 1.2.3 Treatment Options
  • 1.2.4 Spinal Fusion
• 1.3 Thoracolumbar Fusion Devices
  • 1.3.1 Implant Design
  • 1.3.2 Thoracolumbar Pathology
• 1.4 Interbody Fusion Devices
  • 1.4.1 Implant Design
  • 1.4.2 Implant Material
  • 1.4.3 Surgical Approach
  • 1.4.4 Note on Interbody Fusion Device Classification

2.0 EUROPEAN MINIMALLY INVASIVE SPINAL FUSION MARKET

• 2.1 Market Overview
• 2.2 Minimally Invasive Spinal Fusion Definitions
• 2.3 Market Analysis
  • 2.3.1 Procedures
  • 2.3.2 Market Forecast
  • 2.3.3 Market Drivers and Limiters
• 2.4 Competitive Analysis
  • 2.4.1 Leading Competitors
  • 2.4.2 Other/Emerging Competitors

3.0 FRENCH MINIMALLY INVASIVE SPINAL FUSION MARKET

• 3.1 Market Overview
• 3.2 Market Analysis
  • 3.2.1 Procedures
    • 3.2.1.1 MI TL Fusions
    • 3.2.1.2 MI IBD Fusions
    • 3.2.1.3 MI Access Instrumentation
  • 3.2.2 Market Forecast
    • 3.2.2.1 MI Traditional TL Implant Market
    • 3.2.2.2 MI IBD Market
  • 3.2.3 Market Drivers and Limiters
• 3.3 Competitive Analysis

4.0 GERMAN MINIMALLY INVASIVE SPINAL FUSION MARKET

• 4.1 Market Overview
• 4.2 Market Analysis
  • 4.2.1 Procedures
    • 4.2.1.1 MI TL Fusions
    • 4.2.1.2 MI IBD Fusions
    • 4.2.1.3 MI Access Instrumentation
  • 4.2.2 Market Forecast
    • 4.2.2.1 MI Traditional TL Implant Market
    • 4.2.2.2 MI IBD Market
  • 4.2.3 Market Drivers and Limiters
• 4.3 Competitive Analysis

5.0 ITALIAN MINIMALLY INVASIVE SPINAL FUSION MARKET

• 5.1 Market Overview
• 5.2 Market Analysis
  • 5.2.1 Procedures
    • 5.2.1.1 MI TL Fusions
    • 5.2.1.2 MI IBD Fusions
    • 5.2.1.3 MI Access Instrumentation
  • 5.2.2 Market Forecast
    • 5.2.2.1 MI Traditional TL Implant Market
    • 5.2.2.2 MI IBD Market
  • 5.2.3 Market Drivers and Limiters
• 5.3 Competitive Analysis

6.0 SPANISH MINIMALLY INVASIVE SPINAL FUSION MARKET

• 6.1 Market Overview
• 6.2 Market Analysis
  • 6.2.1 Procedures
    • 6.2.1.1 MI TL Fusions
    • 6.2.1.2 MI IBD Fusions
    • 6.2.1.3 MI Access Instrumentation
  • 6.2.2 Market Forecast
    • 6.2.2.1 MI Traditional TL Implant Market
    • 6.2.2.2 MI IBD Market
  • 6.2.3 Market Drivers and Limiters
• 6.3 Competitive Analysis

7.0 UK MINIMALLY INVASIVE SPINAL FUSION MARKET

• 7.1 Market Overview
• 7.2 Market Analysis
  • 7.2.1 Procedures
    • 7.2.1.1 MI TL Fusions
    • 7.2.1.2 MI IBD Fusions
    • 7.2.1.3 MI Access Instrumentation
  • 7.2.2 Market Forecast
    • 7.2.2.1 MI Traditional TL Implant Market
    • 7.2.2.2 MI IBD Market
  • 7.2.3 Market Drivers and Limiters
• 7.3 Competitive Analysis

APPENDIX A: MRG ACRONYMS AND INITIALISMS

List of Exhibits

METHODOLOGY

• Exhibit M-1 : Currency Exchange Rates, 2006

EXECUTIVE SUMMARY

• Exhibit ES-1 : MI Spinal Fusion Market, by Country, Europe (US$), 2005-2011
• Exhibit ES-2 : Open and MI Traditional Thoracolumbar Implant Procedures, France, 2005-2011
• Exhibit ES-3 : MI Traditional Thoracolumbar Instrumentation Market, by Instrumentation, Germany (US$), 2005-2011
• Exhibit ES-4 : MI Thoracolumbar Spine Fusion Market, Italy (US$), 2005-2011
• Exhibit ES-5 : MI Thoracolumbar Spine Fusion Procedures, Spain, 2005-2011
• Exhibit ES-6 : MI TL Spine Fusion Market, by Instrumentation, UK (US$), 2005-2011
• Exhibit ES-7 : Leading Competitors in the MI Spinal Fusion Market, as a % of Total, Europe, 2006

CHAPTER 1: MINIMALLY INVASIVE SPINAL FUSION DEVICE OVERVIEW

• Exhibit 1-1 : Roles of the Spinal Column
• Exhibit 1-2 : Instrumented Spinal Fusion Procedure Classification
• Exhibit 1-3 : IBD Classification

CHAPTER 2: EUROPEAN MINIMALLY INVASIVE SPINAL FUSION MARKET

• Exhibit 2-1 : MI IBD Spinal Fusion Procedures, by Approach, UK, 2005-2011
• Exhibit 2-2 : Procedural Definitions
• Exhibit 2-3 : Market Value Definitions
• Exhibit 2-4 : MI TL Spinal Fusion Procedures, Europe, 2005-2011
• Exhibit 2-5 : MI TL Spinal Fusion Procedures, by Procedure Type and Country, Europe, 2005-2011
• Exhibit 2-6 : MI TL Spinal Fusion Procedural Growth, by Procedure Type and Country, Europe, 2006-2011
• Exhibit 2-7 : MI Spinal Fusion Market, by Country, Europe (US$), 2005-2011
• Exhibit 2-8 : MI Spinal Fusion Market, by Country, Europe (€), 2005-2011
• Exhibit 2-9 : Drivers of the MI Spinal Fusion Market, Europe
• Exhibit 2-10 : Limiters of the MI Spinal Fusion Market, Europe
• Exhibit 2-11 : Leading Competitors in the MI Spinal Fusion Market, Europe, 2006
• Exhibit 2-12 : Select Minimally Invasive Spine Products, Europe, 2006
• Exhibit 2-13 : Select Minimally Invasive Spine Products, Europe, 2006 (continued)

CHAPTER 3: FRENCH MINIMALLY INVASIVE SPINAL FUSION MARKET

• Exhibit 3-1 : MI TL Spinal Fusion Procedures, as a % of Traditional Instrumented TL Spinal Fusions, France, 2005-2011
• Exhibit 3-2 : MI TL Spinal Fusion Procedures, France, 2005-2011
• Exhibit 3-3 : MI IBD Spinal Fusion Procedures, France, 2005-2011
• Exhibit 3-4 : MI IBD Spinal Fusion Procedures, by Approach, France, 2005-2011
• Exhibit 3-5 : MI Spinal Fusion Access Instrumentation, France, 2005-2011
• Exhibit 3-6 : MI Spinal Fusion Market, by Device, France (US$), 2005-2011
• Exhibit 3-7 : MI Spinal Fusion Market, by Device, France (€), 2005-2011
• Exhibit 3-8 : MI TL Implant Market, France (US$), 2005-2011
• Exhibit 3-9 : MI TL Implant Market, France (€), 2005-2011
• Exhibit 3-10 : TL Implant ASP per Procedure, by Surgery Type, France (US$), 2005-2011
• Exhibit 3-11 : TL Implant ASP per Procedure, by Surgery Type, France (€), 2005-2011
• Exhibit 3-12 : MI TL Implant System ASPs per Procedure, by Number of Levels, France (US$), 2005-2011
• Exhibit 3-13 : MI TL Implant System ASPs per Procedure, by Number of Levels, France (€), 2005-2011
• Exhibit 3-14 : MI IBD Market, by Approach, as a % of Total, France (US$), 2005-2011
• Exhibit 3-15 : MI IBD Market, by Approach, as a % of Total, France (€), 2005-2011
• Exhibit 3-16 : MI IBD Market, by Approach, France (US$), 2005-2011
• Exhibit 3-17 : MI IBD Market, by Approach, France (€), 2005-2011
• Exhibit 3-18 : Drivers of the MI Spinal Fusion Market, France
• Exhibit 3-19 : Limiters of the MI Spinal Fusion Market, France
• Exhibit 3-20 : Leading Competitors in the MI Spinal Fusion Market, France, 2006

CHAPTER 4: GERMAN MINIMALLY INVASIVE SPINAL FUSION MARKET

• Exhibit 4-1 : MI Spinal Fusion Market, by Device, Germany (US$), 2005-2011
• Exhibit 4-2 : MI TL Spinal Fusion Procedures, Germany, 2005-2011
• Exhibit 4-3 : MI IBD Spinal Fusion Procedures, Germany, 2005-2011
• Exhibit 4-4 : MI IBD Spinal Fusion Procedures, by Approach, Germany, 2005-2011
• Exhibit 4-5 : MI Spinal Fusion Access Instrumentation, Germany, 2005-2011
• Exhibit 4-6 : MI Spinal Fusion Market, by Device, Germany (US$), 2005-2011 (Tabular Format)
• Exhibit 4-7 : MI Spinal Fusion Market, by Device, Germany (€), 2005-2011
• Exhibit 4-8 : MI TL Implant Market, Germany (US$), 2005-2011
• Exhibit 4-9 : MI TL Implant Market, Germany (€), 2005-2011
• Exhibit 4-10 : TL Implant ASP per Procedure, by Surgery Type, Germany (US$), 2005-2011
• Exhibit 4-11 : TL Implant ASP per Procedure, by Surgery Type, Germany (€), 2005-2011
• Exhibit 4-12 : MI TL Implant System ASPs per Procedure, by Number of Levels, Germany (US$), 2005-2011
• Exhibit 4-13 : MI TL Implant System ASPs per Procedure, by Number of Levels, Germany (€), 2005-2011
• Exhibit 4-14 : MI IBD Market, by Approach, Germany (US$), 2005-2011
• Exhibit 4-15 : MI IBD Market, by Approach, Germany (€), 2005-2011
• Exhibit 4-16 : MI IBD Market, by Approach, Germany (US$), 2005-2011
• Exhibit 4-17 : MI IBD Market, by Approach, Germany (€), 2005-2011
• Exhibit 4-18 : Drivers of the MI Spinal Fusion Market, Germany
• Exhibit 4-19 : Limiters of the MI Spinal Fusion Market, Germany
• Exhibit 4-20 : Leading Competitors in the MI Spinal Fusion Market, Germany, 2006

CHAPTER 5: ITALIAN MINIMALLY INVASIVE SPINAL FUSION MARKET

• Exhibit 5-1 : MI Spinal Fusion Market, Italy, 2005-2011
• Exhibit 5-2 : MI TL Spinal Fusion Procedures, Italy, 2005-2011
• Exhibit 5-3 : MI IBD Spinal Fusion Procedures, Italy, 2005-2011
• Exhibit 5-4 : MI IBD Spinal Fusion Procedures, by Approach, Italy, 2005-2011
• Exhibit 5-5 : MI Spinal Fusion Access Instrumentation, Italy, 2005-2011
• Exhibit 5-6 : MI Spinal Fusion Market, by Device, Italy (US$), 2005-2011
• Exhibit 5-7 : MI Spinal Fusion Market, by Device, Italy (€), 2005-2011
• Exhibit 5-8 : MI TL Implant Market, Italy (US$), 2005-2011
• Exhibit 5-9 : MI TL Implant Market, Italy (€), 2005-2011
• Exhibit 5-10 : TL Implant ASP per Procedure, by Surgery Type, Italy (US$), 2005-2011
• Exhibit 5-11 : TL Implant ASP per Procedure, by Surgery Type, Italy (€), 2005-2011
• Exhibit 5-12 : MI TL Implant System ASPs per Procedure, by Number of Levels, Italy (US$), 2005-2011
• Exhibit 5-13 : MI TL Implant System ASPs per Procedure, by Number of Levels, Italy (€), 2005-2011
• Exhibit 5-14 : MI IBD Market, by Approach, as a % of Total, Italy (US$), 2005-2011
• Exhibit 5-15 : MI IBD Market, by Approach, as a % of Total, Italy (€), 2005-2011
• Exhibit 5-16 : MI IBD Market, by Approach, Italy (US$), 2005-2011
• Exhibit 5-17 : MI IBD Market, by Approach, Italy (€), 2005-2011
• Exhibit 5-18 : Drivers of the MI Spinal Fusion Market, Italy
• Exhibit 5-19 : Limiters of the MI Spinal Fusion Market, Italy
• Exhibit 5-20 : Leading Competitors in the MI Spinal Fusion Market, Italy, 2006

CHAPTER 6: SPANISH MINIMALLY INVASIVE SPINAL FUSION MARKET

• Exhibit 6-1 : MI Thoracolumbar Procedure Volumes, Spain, 2005-2011
• Exhibit 6-2 : MI TL Spinal Fusion Procedures, Spain, 2005-2011
• Exhibit 6-3 : MI IBD Spinal Fusion Procedures, Spain, 2005-2011
• Exhibit 6-4 : MI IBD Spinal Fusion Procedures, by Approach, Spain, 2005-2011
• Exhibit 6-5 : MI Spinal Fusion Access Instrumentation, Spain, 2005-2011
• Exhibit 6-6 : MI Spinal Fusion Market, by Device, Spain (US$), 2005-2011 (Tabular Format)
• Exhibit 6-7 : MI Spinal Fusion Market, by Device, Spain (€), 2005-2011 (Tabular Format)
• Exhibit 6-8 : MI TL Implant Market, Spain (US$), 2005-2011 (Tabular Format)
• Exhibit 6-9 : MI TL Implant Market, Spain (€), 2005-2011 (Tabular Format)
• Exhibit 6-10 : TL Implant ASP per Procedure, by Surgery Type, Spain (US$), 2005-2011
• Exhibit 6-11 : TL Implant ASP per Procedure, by Surgery Type, Spain (€), 2005-2011
• Exhibit 6-12 : MI TL Implant System ASPs per Procedure, by Number of Levels, Spain (US$), 2005-2011
• Exhibit 6-13 : MI TL Implant System ASPs per Procedure, by Number of Levels, Spain (€), 2005-2011
• Exhibit 6-14 : MI IBD Market, by Type and by Approach, Spain (US$), 2005-2011
• Exhibit 6-15 : MI IBD Market, by Type and by Approach, Spain (€), 2005-2011
• Exhibit 6-16 : MI TLIF IBD Market, by Type, Spain (US$), 2005-2011
• Exhibit 6-17 : MI TLIF IBD Market, by Type, Spain (€), 2005-2011
• Exhibit 6-18 : Drivers of the MI Spinal Fusion Market, Spain
• Exhibit 6-19 : Limiters of the MI Spinal Fusion Market, Spain
• Exhibit 6-20 : Leading Competitors in the MI Spinal Fusion Market, Spain, 2006

CHAPTER 7: UK MINIMALLY INVASIVE SPINAL FUSION MARKET

• Exhibit 7-1 : MI Spinal Fusion Market, by Device, UK (US$), 2005-2011
• Exhibit 7-2 : MI TL Spinal Fusion Procedures, UK, 2005-2011
• Exhibit 7-3 : MI IBD Spinal Fusion Procedures, UK, 2005-2011
• Exhibit 7-4 : MI IBD Spinal Fusion Procedures, by Approach, UK, 2005-2011
• Exhibit 7-5 : MI Spinal Fusion Access Instrumentation, UK, 2005-2011
• Exhibit 7-6 : MI Spinal Fusion Market, by Device, UK (US$), 2005-2011
• Exhibit 7-7 : MI Spinal Fusion Market, by Device, UK (€), 2005-2011
• Exhibit 7-8 : MI Spinal Fusion Market, by Device, UK (£), 2005-2011
• Exhibit 7-9 : MI Traditional TL Implant Market, UK (US$), 2005-2011
• Exhibit 7-10 : MI Traditional TL Implant Market, UK (€), 2005-2011
• Exhibit 7-11 : MI Traditional TL Implant Market, UK (£), 2005-2011
• Exhibit 7-12 : Traditional TL Implant ASP per Procedure, by Surgery Type, UK (US$), 2005-2011
• Exhibit 7-13 : Traditional TL Implant ASP per Procedure, by Surgery Type, UK (€), 2005-2011
• Exhibit 7-14 : Traditional TL Implant ASP per Procedure, by Surgery Type, UK (£), 2005-2011
• Exhibit 7-15 : MI Traditional TL Implant System ASPs per Procedure, by Number of Levels, UK (US$), 2005-2011
• Exhibit 7-16 : MI Traditional TL Implant System ASPs per Procedure, by Number of Levels, UK (€), 2005-2011
• Exhibit 7-17 : MI Traditional TL Implant System ASPs per Procedure, by Number of Levels, UK (£), 2005-2011
• Exhibit 7-18 : MI IBD Market, by Approach, as a % of Total, UK (US$), 2005-2011
• Exhibit 7-19 : MI IBD Market, by Approach, as a % of Total, UK (€), 2005-2011
• Exhibit 7-20 : MI IBD Market, by Approach, as a % of Total, UK (£), 2005-2011
• Exhibit 7-21 : MI IBD Market, by Approach, UK (US$), 2005-2011
• Exhibit 7-22 : MI IBD Market, by Approach UK (€), 2005-2011
• Exhibit 7-23 : MI IBD Market, by Approach, UK (£), 2005-2011
• Exhibit 7-24 : Drivers of the MI Spinal Fusion Market, UK
• Exhibit 7-25 : Limiters of the MI Spinal Fusion Market, UK
• Exhibit 7-26 : Leading Competitors in the MI Spinal Fusion Market, UK, 2006