Global Markets for Minimally Invasive VCF Treatments 2007

Table of Contents

TABLE OF CONTENTS

LIST OF EXHIBITS

EXECUTIVE SUMMARY

METHODOLOGY

1.0 VERTEBRAL COMPRESSION FRACTURE OVERVIEW

• 1.1 Anatomy of the Human Spine
• 1.2 Selected Spinal Disorders
  • 1.2.1 Osteoporosis
  • 1.2.2 Rheumatoid Arthritis
  • 1.2.3 Kyphosis
  • 1.2.4 Traumatic Spine Disorders
  • 1.2.5 Spinal Tumor Disorders
• 1.3 Vertebral Compression Fractures
  • 1.3.1 Treatment Options
    • 1.3.1.1 Nonsurgical
    • 1.3.1.2 Surgical
    • 1.3.1.3 Noninvasive Approach
• 1.4 Vertebroplasty
  • 1.4.1 Approach
  • 1.4.2 Mechanism of Action
  • 1.4.3 Potential Complications
  • 1.4.4 Indications/Contraindications
• 1.5 Kyphoplasty
• 1.6 Vertebroplasty versus Kyphoplasty
• 1.7 Injectable Bone Cement
• 1.8 Cement Delivery Systems

2.0 GLOBAL MINIMALLY INVASIVE VERTEBRAL COMPRESSION FRACTURE TREATMENT MARKET

• 2.1 Market Overview
• 2.2 Market Analysis
  • 2.2.1 Procedures
  • 2.2.2 Market Forecast
  • 2.2.3 Market Drivers & Limiters
    • 2.2.3.1 Market Drivers
    • 2.2.3.2 Market Limiters
• 2.3 Competitive Analysis
  • 2.3.1 Emerging Competitors

3.0 US MINIMALLY INVASIVE VERTEBRAL COMPRESSION FRACTURE TREATMENT MARKET

• 3.1 Market Overview
• 3.2 Market Analysis
  • 3.2.1 Procedures
  • 3.2.2 Market Forecast
  • 3.2.3 Market Drivers and Limiters
    • 3.2.3.1 Market Drivers
    • 3.2.3.2 Market Limiters
• 3.3 Competitive Analysis

4.0 EUROPEAN MINIMALLY INVASIVE VERTEBRAL COMPRESSION FRACTURE TREATMENT MARKET

• 4.1 Market Overview
• 4.2 Market Analysis
  • 4.2.1 Procedures
  • 4.2.2 Market Forecast
  • 4.2.3 Market Drivers and Limiters
    • 4.2.3.1 Market Drivers
    • 4.2.3.2 Market Limiters
• 4.3 Competitive Analysis
• 4.4 French Minimally Invasive Vertebral Compression Fracture Treatment Market
  • 4.4.1 Market Analysis
  • 4.4.2 Market Drivers and Limiters
    • 4.4.2.1 Market Drivers
    • 4.4.2.2 Market Limiters
  • 4.4.3 Competitive Analysis
• 4.5 German Minimally Invasive Vertebral Compression Fracture Treatment Market
  • 4.5.1 Market Analysis
  • 4.5.2 Market Drivers and Limiters
    • 4.5.2.1 Market Drivers
    • 4.5.2.2 Market Limiters
  • 4.5.3 Competitive Analysis
• 4.6 Italian Minimally Invasive Vertebral Compression Fracture Treatment Market
  • 4.6.1 Market Analysis
  • 4.6.2 Market Drivers and Limiters
    • 4.6.2.1 Market Drivers
    • 4.6.2.2 Market Limiters
  • 4.6.3 Competitive Analysis
• 4.7 UK Minimally Invasive Vertebral Compression Fracture Treatment Market
  • 4.7.1 Market Analysis
  • 4.7.2 Market Drivers and Limiters
    • 4.7.2.1 Market Drivers
    • 4.7.2.2 Market Limiters
  • 4.7.3 Competitive Analysis

5.0 ASIA PACIFIC MINIMALLY INVASIVE VERTEBRAL COMPRESSION FRACTURE TREATMENT MARKET

• 5.1 Market Overview
• 5.2 Market Analysis
  • 5.2.1 Procedures
  • 5.2.2 Market Forecast
  • 5.2.3 Market Drivers and Limiters
    • 5.2.3.1 Market Drivers
    • 5.2.3.2 Market Limiters
• 5.3 Competitive Analysis
• 5.4 Australian Minimally Invasive Vertebral Compression Fracture Treatment Market
  • 5.4.1 Market Analysis
  • 5.4.2 Market Drivers and Limiters
    • 5.4.2.1 Market Drivers
    • 5.4.2.2 Market Limiters
  • 5.4.3 Competitive Analysis
• 5.5 Japanese Minimally Invasive Vertebral Compression Fracture Treatment Market
  • 5.5.1 Market Analysis
  • 5.5.2 Market Drivers and Limiters
    • 5.5.2.1 Market Drivers
    • 5.5.2.2 Market Limiters
  • 5.5.3 Competitive Analysis
• 5.6 South Korean Minimally Invasive Vertebral Compression Fracture Treatment Market
  • 5.6.1 Market Analysis
  • 5.6.2 Market Drivers and Limiters
    • 5.6.2.1 Market Drivers
    • 5.6.2.2 Market Limiters
  • 5.6.3 Competitive Analysis

APPENDIX A: MRG ACRONYMS & INITIALISMS

APPENDIX B: OSTEOPOROSIS EPIDEMIOLOGY

List of Exhibits

EXECUTIVE SUMMARY

• Exhibit 1: MIVCF Treatment Market, by Region, Global (US$), 2005-2011
• Exhibit 2: Kyphoplasty Procedures, Global, 2005-2011
• Exhibit 3: Vertebroplasty Procedures, Global, 2005-2011
• Exhibit 4: MIVCF Treatment Market, by Segment, US (US$), 2005-2011
• Exhibit 5: MIVCF Treatment Market, as a % of Total, by Country, Europe, 2005-2011
• Exhibit 6: MIVCF Treatment Market, by Segment, Asia Pacific (US$), 2005-2011
• Exhibit 7: Leading Competitors in the MIVCF Market, Global, 2006

METHODOLOGY

• Exhibit 8: Currency Exchange Rates, 2006

CHAPTER 1: VERTEBRAL COMPRESSION FRACTURE OVERVIEW

• Exhibit 9: Roles of the Spinal Column
• Exhibit 10: Potential Complications of Vertebroplasty
• Exhibit 11: Selected Contraindications to Vertebroplasty
• Exhibit 12: Vertebroplasty versus Kyphoplasty
• Exhibit 13: Selected Bone Cement for MIVCF treatments
• Exhibit 14: Selected Cement Delivery Systems and Accessories

CHAPTER 2: GLOBAL MINIMALLY INVASIVE VERTEBRAL COMPRESSION FRACTURE TREATMENT MARKET

• Exhibit 15: MIVCF Treatment Market, Global, 2005-2011
• Exhibit 16: MIVCF Treatment Procedures, By Segment, Global, 2005-2011
• Exhibit 17: MIVCF Treatment Procedures, By Segment and by Region, Global, 2005-2011
• Exhibit 18: Total MIVCF Treatment Procedures, by Region, Global, 2005-2011
• Exhibit 19: MIVCF Market, By Segment, Global (US$), 2005-2011
• Exhibit 20: MIVCF Treatment Market, by Segment and Region, Global (US$), 2005-2011
• Exhibit 21: Total MIVCF Treatment Market, by Region, Global (US$), 2005-2011
• Exhibit 22: Drivers and Limiters of the MIVCF Market, Global
• Exhibit 23: Leading Competitors in the MIVCF Market, by Segment, as a % of Total, Global, 2006
• Exhibit 24: Leading Competitors in the Vertebroplasty Market, as a % of Total, Global, 2006
• Exhibit 25: Kyphon Clinical Trials, Global, 2006

CHAPTER 3: US MINIMALLY INVASIVE VERTEBRAL COMPRESSION FRACTURE TREATMENT MARKET

• Exhibit 26: MIVCF Treatment Procedures, by Segment, US, 2005-2011 (Graphical Format)
• Exhibit 27: MIVCF Treatment Procedures, by Segment, US, 2005-2011 (Tabular Format)
• Exhibit 28: MIVCF Treatment Levels per Procedure, by Segment, as a % of Total, US, 2005-2011
• Exhibit 29: MIVCF Treatment Levels, by Segment, US, 2005-2011
• Exhibit 30: MIVCF Treatment Market, by Segment, US (US$), 2005-2011
• Exhibit 31: MIVCF Market Growth, by Segment, US, 2006-2011
• Exhibit 32: MIVCF Treatment ASP, by Segment and Component, US (US$), 2005-2011
• Exhibit 33: MIVCF Treatment Bone Cement Market, by Segment, US (US$), 2005-2011
• Exhibit 34: MIVCF Treatment Delivery System Market, by Segment, US (US$), 2005-2011
• Exhibit 35: Drivers of the MIVCF Treatment Market, US
• Exhibit 36: Limiters of the MIVCF Treatment Market, US
• Exhibit 37: Leading Competitors in the MIVCF Treatment Market, by Segment, as a % of Total, US, 2006
• Exhibit 38: Leading Competitors in the MIVCF Treatment Bone Cement Market, by Segment, as a % of Total, US, 2006
• Exhibit 39: Leading Competitors in the MIVCF Treatment Delivery Systems Market, by Segment, as a % of Total, US, 2006

CHAPTER 4: EUROPEAN MINIMALLY INVASIVE VERTEBRAL COMPRESSION FRACTURE TREATMENT MARKET

• Exhibit 40: MIVCF Treatment Market, by Country, Europe (US$), 2005-2011
• Exhibit 41: MIVCF Treatment Procedures, by Segment, Europe, 2005-2011
• Exhibit 42: MIVCF Treatment Procedures, by Segment and Country, Europe, 2005-2011
• Exhibit 43: Total MIVCF Treatment Procedures, by Country, Europe, 2005-2011
• Exhibit 44: MIVCF Treatment Levels, by Segment, Europe, 2005-2011
• Exhibit 45: MIVCF Treatment Market, by Segment, Europe, (US$ and €), 2005-2011
• Exhibit 46: Vertebroplasty Market, by Country, Europe (US$ and €), 2005-2011
• Exhibit 47: Kyphoplasty Market, by Country, Europe (US$ and €), 2005-2011
• Exhibit 48: MIVCF Treatment Bone Cement Market, by Segment, Europe, (US$ and €), 2005-2011
• Exhibit 49: MIVCF Treatment Delivery Systems Market, by Segment, Europe, (US$ and €), 2005-2011
• Exhibit 50: MIVCF Treatment Bone Cement Market, by Country, Europe (US$ and €), 2005-2011
• Exhibit 51: MIVCF Treatment Delivery Systems Market, by Country, Europe (US$ and €), 2005-2011
• Exhibit 52: Drivers and Limiters of the MIVCF Treatment Market, Europe
• Exhibit 53: Leading Competitors in the MIVCF Treatment Market, by Segment, as a % of Total, Europe, 2006
• Exhibit 54: Leading Competitors in the MIVCF Treatment Market, by Country, as a % of Total, Europe, 2006
• Exhibit 55: MIVCF Treatment Procedures, by Segment, France, 2005-2011
• Exhibit 56: MIVCF Treatment Levels per Procedure, by Segment, as a % of Total, France, 2005-2011
• Exhibit 57: MIVCF Treatment Levels, by Segment, France, 2005-2011
• Exhibit 58: MIVCF Treatment Market, by Segment, France (US$ and €), 2005-2011
• Exhibit 59: MIVCF Market Growth, by Segment, France, 2006-2011
• Exhibit 60: MIVCF Treatment ASP, by Segment and Component, France (US$ and €), 2005-2011
• Exhibit 61: MIVCF Treatment Bone Cement Market, by Segment, France (US$), 2005-2011
• Exhibit 62: MIVCF Treatment Bone Cement Market, by Segment, France (€), 2005-2011
• Exhibit 63: MIVCF Treatment Delivery Systems Market, by Segment, France (US$), 2005-2011
• Exhibit 64: MIVCF Treatment Delivery Systems Market, by Segment, France (€), 2005-2011
• Exhibit 65: Drivers of the MIVCF Treatment Market, France
• Exhibit 66: Limiters of the MIVCF Treatment Market, France
• Exhibit 67: Leading Competitors in the MIVCF Treatment Market, by Segment, as a % of Total, France, 2006
• Exhibit 68: MIVCF Treatment Procedures, by Segment, Germany, 2005-2011
• Exhibit 69: MIVCF Treatment Levels per Procedure, by Segment, as a % of Total, Germany, 2005-2011
• Exhibit 70: MIVCF Treatment Levels, by Segment, Germany, 2005-2011
• Exhibit 71: MIVCF Treatment Market, by Segment, Germany (US$ and €), 2005-2011
• Exhibit 72: MIVCF Market Growth, by Segment, Germany, 2006-2011
• Exhibit 73: MIVCF Treatment ASP, by Segment and Component, Germany (US$ and €), 2005-2011
• Exhibit 74: MIVCF Treatment Bone Cement Market, by Segment, Germany (US$), 2005-2011
• Exhibit 75: MIVCF Treatment Bone Cement Market, by Segment, Germany (€), 2005-2011
• Exhibit 76: MIVCF Treatment Delivery Systems Market, by Segment, Germany (US$), 2005-2011
• Exhibit 77: MIVCF Treatment Delivery Systems Market, by Segment, Germany (€), 2005-2011
• Exhibit 78: Drivers of the MIVCF Treatment Market, Germany
• Exhibit 79: Limiters of the MIVCF Treatment Market, Germany
• Exhibit 80: Leading Competitors in the MIVCF Treatment Market, by Segment, as a % of Total, Germany, 2006
• Exhibit 81: MIVCF Treatment Procedures, by Segment, Italy, 2005-2011
• Exhibit 82: MIVCF Treatment Levels per Procedure, by Segment, as a % of Total, Italy, 2005-2011
• Exhibit 83: MIVCF Treatment Levels, by Segment, Italy, 2005-2011
• Exhibit 84: MIVCF Treatment Market, by Segment, Italy (US$ and €), 2005-2011
• Exhibit 85: MIVCF Market Growth, by Segment, Italy, 2006-2011
• Exhibit 86: MIVCF Treatment ASP, by Segment and Component, Italy (US$ and €), 2005-2011
• Exhibit 87: MIVCF Treatment Bone Cement Market, by Segment, Italy (US$), 2005-2011
• Exhibit 88: MIVCF Treatment Bone Cement Market, by Segment, Italy (€), 2005-2011
• Exhibit 89: MIVCF Treatment Delivery Systems Market, by Segment, Italy (US$), 2005-2011
• Exhibit 90: MIVCF Treatment Delivery Systems Market, by Segment, Italy (€), 2005-2011
• Exhibit 91: Drivers of the MIVCF Treatment Market, Italy
• Exhibit 92: Limiters of the MIVCF Treatment Market, Italy
• Exhibit 93: Leading Competitors in the MIVCF Treatment Market, by Segment, as a % of Total, Italy, 2006
• Exhibit 94: MIVCF Treatment Procedures, by Segment, UK, 2005-2011
• Exhibit 95: MIVCF Treatment Levels per Procedure, by Segment, as a % of Total, UK, 2005-2011
• Exhibit 96: MIVCF Treatment Levels, by Segment, UK, 2005-2011
• Exhibit 97: MIVCF Treatment Market, by Segment, UK (US$), 2005-2011
• Exhibit 98: MIVCF Treatment Market, by Segment, UK (€), 2005-2011
• Exhibit 99: MIVCF Treatment Market, by Segment, UK (£), 2005-2011
• Exhibit 100: MIVCF Market Growth, by Segment, UK, 2006-2011
• Exhibit 101: MIVCF Treatment ASP, by Segment and Component, UK (US$, €, and £), 2005-2011
• Exhibit 102: MIVCF Treatment Bone Cement Market, by Segment, UK (US$), 2005-2011
• Exhibit 103: MIVCF Treatment Bone Cement Market, by Segment, UK (€), 2005-2011
• Exhibit 104: MIVCF Treatment Bone Cement Market, by Segment, UK (£), 2005-2011
• Exhibit 105: MIVCF Treatment Delivery Systems Market, by Segment, UK (US$), 2005-2011
• Exhibit 106: MIVCF Treatment Delivery Systems Market, by Segment, UK (€), 2005-2011
• Exhibit 107: MIVCF Treatment Delivery Systems Market, by Segment, UK (£), 2005-2011
• Exhibit 108: Drivers of the MIVCF Treatment Market, UK
• Exhibit 109: Limiters of the MIVCF Treatment Market, UK
• Exhibit 110: Leading Competitors in the MIVCF Treatment Market, by Segment, as a % of Total, UK, 2006

CHAPTER 5: ASIA PACIFIC MINIMALLY INVASIVE VERTEBRAL COMPRESSION FRACTURE TREATMENT MARKET

• Exhibit 111: MIVCF Treatment Procedures, Asia Pacific, 2005-2011
• Exhibit 112: MIVCF Treatment Procedures, by Segment, Asia Pacific, 2005-2011
• Exhibit 113: MIVCF Treatment Procedures, by Segment and Country, Asia Pacific, 2005-2011
• Exhibit 114: MIVCF Treatment Levels, by Segment, Asia Pacific, 2005-2011
• Exhibit 115: MIVCF Treatment Market, by Segment, Asia Pacific, (US$), 2005-2011
• Exhibit 116: MIVCF Treatment Market, by Segment and Country, Asia Pacific (US$), 2005-2011
• Exhibit 117: MIVCF Treatment Bone Cement Market, by Segment, Asia Pacific, (US$), 2005-2011
• Exhibit 118: MIVCF Treatment Delivery Systems Market, by Segment, Asia Pacific, (US$), 2005-2011
• Exhibit 119: MIVCF Treatment Bone Cement Market, by Country, Asia Pacific (US$), 2005-2011
• Exhibit 120: MIVCF Treatment Delivery Systems Market, by Country, Asia Pacific (US$), 2005-2011
• Exhibit 121: Drivers and Limiters of the MIVCF Treatment Market, Asia Pacific
• Exhibit 122: Population Division, Total and Over 65, Asia Pacific, 2000-2050
• Exhibit 123: Leading Competitors in the MIVCF Treatment Market, by Segment, as a % of Total, Asia Pacific, 2006
• Exhibit 124: Leading Competitors in the MIVCF Treatment Market, by Country, as a % of Total, Asia Pacific, 2006
• Exhibit 125: MIVCF Treatment Procedures, by Segment, Australia, 2005-2011
• Exhibit 126: MIVCF Treatment Levels per Procedure, by Segment, as a % of Total, Australia, 2005-2011
• Exhibit 127: MIVCF Treatment Levels, by Segment, Australia, 2005-2011
• Exhibit 128: MIVCF Treatment Market, by Segment, Australia (US$ and AU$), 2005-2011
• Exhibit 129: MIVCF Market Growth, by Segment, Australia, 2006-2011
• Exhibit 130: MIVCF Treatment ASP, by Segment and Component, Australia (US$ and AU$), 2005-2011
• Exhibit 131: MIVCF Treatment Bone Cement Market, by Segment, Australia (US$), 2005-2011
• Exhibit 132: MIVCF Treatment Bone Cement Market, by Segment, Australia (AU$), 2005-2011
• Exhibit 133: MIVCF Treatment Delivery Systems Market, by Segment, Australia (US$), 2005-2011
• Exhibit 134: MIVCF Treatment Delivery Systems Market, by Segment, Australia (AU$), 2005-2011
• Exhibit 135: Drivers of the MIVCF Treatment Market, Australia
• Exhibit 136: Limiters of the MIVCF Treatment Market, Australia
• Exhibit 137: Leading Competitors in the MIVCF Treatment Market, by Segment, as a % of Total, Australia, 2006
• Exhibit 138: MIVCF Treatment Procedures, by Segment, Japan, 2005-2011
• Exhibit 139: MIVCF Treatment Levels per Procedure, by Segment, as a % of Total, Japan, 2005-2011
• Exhibit 140: MIVCF Treatment Levels, by Segment, Japan, 2005-2011
• Exhibit 141: MIVCF Treatment Market, by Segment, Japan (US$ and ¥), 2005-2011
• Exhibit 142: MIVCF Treatment Market Growth, by Segment, Japan, 2006-2011
• Exhibit 143: MIVCF Treatment ASP, by Segment and Component, Japan, (US$ and ¥), 2005-2011
• Exhibit 144: MIVCF Treatment Bone Cement Market, by Segment, Japan, (US$), 2005-2011
• Exhibit 145: MIVCF Treatment Bone Cement Market, by Segment, Japan (¥), 2005-2011
• Exhibit 146: MIVCF Treatment Delivery Systems Market, by Segment, Japan (US$), 2005-2011
• Exhibit 147: MIVCF Treatment Delivery Systems Market, by Segment, Japan (¥), 2005-2011
• Exhibit 148: Drivers of the MIVCF Treatment Market, Japan
• Exhibit 149: Limiters of the MIVCF Treatment Market, Japan
• Exhibit 150: Leading Competitors in the MIVCF Treatment Market, as a % of Total, Japan, 2006
• Exhibit 151: MIVCF Treatment Procedures, by Segment, South Korea, 2005-2011
• Exhibit 152: MIVCF Treatment Levels per Procedure, by Segment, as a % of Total, South Korea, 2005-2011
• Exhibit 153: MIVCF Treatment Levels, by Segment, South Korea, 2005-2011
• Exhibit 154: MIVCF Treatment Market, by Segment, South Korea (US$ and W), 2005-2011
• Exhibit 155: MIVCF Market Growth, by Segment, South Korea, 2006-2011
• Exhibit 156: MIVCF Treatment ASP, by Segment and Component, South Korea (US$ and W), 2005-2011
• Exhibit 157: MIVCF Treatment Bone Cement Market, by Segment, South Korea (US$), 2005-2011
• Exhibit 158: MIVCF Treatment Bone Cement Market, by Segment, South Korea (W), 2005-2011
• Exhibit 159: MIVCF Treatment Delivery Systems Market, by Segment, South Korea (US$), 2005-2011
• Exhibit 160: MIVCF Treatment Delivery Systems Market, by Segment, South Korea (W), 2005-2011
• Exhibit 161: Drivers of the MIVCF Treatment Market, South Korea
• Exhibit 162: Limiters of the MIVCF Treatment Market, South Korea
• Exhibit 163: Leading Competitors in the MIVCF Treatment Market, by Segment, as a % of Total, South Korea, 2006

APPENDIX B: OSTEOPOROSIS EPIDEMIOLOGY

• Exhibit 164: Prevalence of Osteoporosis, US, 2005-2011
• Exhibit 165: Prevalence of Osteoporosis, France, 2005-2011
• Exhibit 166: Prevalence of Osteoporosis, Germany, 2005-2011
• Exhibit 167: Prevalence of Osteoporosis, Italy, 2005-2011
• Exhibit 168: Prevalence of Osteoporosis, UK, 2005-2011
• Exhibit 169: Prevalence of Osteoporosis, Japan, 2005-2011