US Markets for Ventricular Assist Devices 2008

Table of Contents

TABLE OF CONTENTS

LIST OF EXHIBITS

EXECUTIVE SUMMARY

METHODOLOGY

1.0 US VENTRICULAR ASSIST DEVICE MARKET

• 1.1 Market Overview
  • 1.1.1 Heart Failure
    • 1.1.1.1 Heart Failure Treatment Options
    • 1.1.1.2 Heart Failure Treatment Patient Indications
• 1.2 Market Analysis
  • 1.2.1 Ventricular Assist Device Clinical Trials
    • 1.2.1.1 Clinical Trial Summaries
    • 1.2.1.2 Clinical Trial Status and Assumptions
  • 1.2.2 Procedures
  • 1.2.3 Market Forecast
  • 1.2.4 Market Drivers and Limiters
    • 1.2.4.1 Market Drivers
    • 1.2.4.2 Market Limiters
• 1.3 Competitive Analysis

2.0 BRIDGE-TO-RECOVERY MARKET

• 2.1 Market Overview
• 2.2 Market Analysis
  • 2.2.1 Procedures
  • 2.2.2 Market Forecast
  • 2.2.3 Market Drivers and Limiters
• 2.3 Competitive Analysis

3.0 BRIDGE-TO-TRANSPLANT MARKET

• 3.1 Market Overview
• 3.2 Market Analysis
  • 3.2.1 Procedures
  • 3.2.2 Market Forecast
  • 3.2.3 Market Drivers and Limiters
• 3.3 Competitive Analysis

4.0 DESTINATION THERAPY MARKET

• 4.1 Market Overview
• 4.2 Market Analysis
  • 4.2.1 Procedures
  • 4.2.2 Market Forecast
  • 4.2.3 Market Drivers and Limiters
• 4.3 Competitive Analysis

APPENDIX A: MRG ACRONYMS AND INITIALISMS

List of Exhibits

• Exhibit 1: VAD Market, by Segment, as a % of Total, US, 2007 and 2012
• Exhibit 2: BTR Unit Model, US, 2006 - 2012
• Exhibit 3: BTT Market Growth, US, 2007 - 2012
• Exhibit 4: DT Penetration Rate, US, 2006 - 2012
• Exhibit 5: Leading and Emerging Competitors in the VAD Market, US, 2007

• Exhibit 6: VAD Market, US (US$), 2006 - 2012
• Exhibit 7: Commercial VAD Availability, US, 2007
• Exhibit 8: Precommercial VADs in Clinical Development, US
• Exhibit 9: HeartMate II BTT Clinical Trial Summary, 2007
• Exhibit 10: HeartMate II DT Clinical Trial Summary, 2007
• Exhibit 11: VentrAssist BTT Clinical Trial Summary, 2007
• Exhibit 12: VentrAssist DT Clinical Trial Summary, 2007
• Exhibit 13: Other VAD Clinical Trial Updates, 2007
• Exhibit 14: Precommercial VAD Clinical Trial Status and Approval Assumptions, US, 2007
• Exhibit 15: VAD Approval Timeline Assumptions, US, 2006 - 2012
• Exhibit 16: VAD Procedures, by Indication, US, 2006 - 2012 (Graphical Format)
• Exhibit 17: VAD Procedures, by Indication, as a % of Total, US, 2006 - 2012
• Exhibit 18: VAD Procedures, by Indication, US, 2006 - 2012 (Tabular Format)
• Exhibit 19: CMS VAD-Related Reimbursement Codes and Rates, 2007
• Exhibit 20: VAD Unit Model, US, 2006 - 2012
• Exhibit 21: VAD Unit Model, by Segment, US, 2006 - 2012
• Exhibit 22: VAD Market, by Segment, US (US$), 2006 - 2012 (Graphical Format)
• Exhibit 23: VAD Market, by Segment, US (US$), 2006 - 2012 (Tabular Format)
• Exhibit 24: VAD Market Growth, by Segment, US, 2007 - 2012 (Graphical Format)
• Exhibit 25: VAD Market Growth, by Segment, US, 2007 - 2012 (Tabular Format)
• Exhibit 26: VAD Market, by Segment, as a % of Total, US, 2007 and 2012
• Exhibit 27: VAD Market, by Segment, as a % of Total, US, 2006 - 2012
• Exhibit 28: Drivers and Limiters of the VAD Market, US
• Exhibit 29: Leading Competitors in the VAD Market, as a % of Total, US, 2007 (Graphical Format)
• Exhibit 30: Leading Competitors in the VAD Market, as a % of Total, US, 2007 (Tabular Format)

• Exhibit 31: BTR Market, US (US$), 2006 - 2012 (Graphical Format)
• Exhibit 32: BTR Procedures, by Patient Type, as a % of Total, US, 2006 - 2012
• Exhibit 33: BTR Procedure Growth, by Patient Type, US, 2007 - 2012
• Exhibit 34: BTR Procedures, by Patient Type, US, 2006 - 2012
• Exhibit 35: Potential BTR Patient Population and VAD Adoption Model, by Patient Type, US, 2006 - 2012
• Exhibit 36: BTR Procedures, Potential Patient Population, and VAD Adoption Model, by Patient Type, US, 2006 - 2012
• Exhibit 37: BTR Procedure and Potential Patient Population Growth, by Patient Type, US, 2007 - 2012
• Exhibit 38: BTR Market Growth, US, 2007 - 2012
• Exhibit 39: BTR VAD Unit Model, US, 2006 - 2012 (Graphical Format)
• Exhibit 40: BTR VAD Unit Model, US, 2006 - 2012 (Tabular Format)
• Exhibit 41: BTR Market, US (US$), 2006 - 2012 (Tabular Format)
• Exhibit 42: Drivers of the BTR Market, US
• Exhibit 43: Limiters of the BTR Market, US
• Exhibit 44: Leading Competitors in the BTR Market, as a % of Total, US, 2007 (Graphical Format)
• Exhibit 45: Leading Competitors in the BTR Market, as a % of Total, US, 2007 (Tabular Format)

• Exhibit 46: BTT Market, US (US$), 2006 - 2012 (Graphical Format)
• Exhibit 47: BTT Procedures, US, 2006 - 2012
• Exhibit 48: BTT Procedures, Potential Patient Population, and VAD Adoption Model, US, 2006 - 2012
• Exhibit 49: BTT VAD Unit Model, US, 2006 - 2012 (Graphical Format)
• Exhibit 50: BTT Market Growth, US, 2007 - 2012
• Exhibit 51: BTT VAD Unit Model, US, 2006 - 2012 (Tabular Format)
• Exhibit 52: BTT Market, US (US$), 2006 - 2012 (Tabular Format)
• Exhibit 53: Drivers of the BTT Market, US
• Exhibit 54: Limiters of the BTT Market, US
• Exhibit 55: Leading Competitors in the BTT Market, as a % of Total, US, (Graphical Format)
• Exhibit 56: Leading Competitors in the BTT Market, as a % of Total, US, (Tabular Format)

• Exhibit 57: DT Market, US (US$), 2006 - 2012 (Graphical Format)
• Exhibit 58: DT Procedures and Penetration Rate, US, 2006 - 2012
• Exhibit 59: DT Procedures and Patient Population Growth, US, 2007 - 2012
• Exhibit 60: DT Procedures, Potential Patient Population, and VAD Adoption Model, US, 2006 - 2012
• Exhibit 61: DT Market Growth, US, 2007 - 2012
• Exhibit 62: DT VAD Unit Model, US, 2006 - 2012
• Exhibit 63: DT Market, US (US$), 2006 - 2012 (Tabular Format)
• Exhibit 64: Drivers of the DT Market, US
• Exhibit 65: Limiters of the DT Market, US