The Future of Personalized Medicine: The impact of proteomics on drug discovery and clinical trial design

Table of Contents

CHAPTER 1: INTRODUCTION TO PROTEOMICS

• The human genome versus the proteome
• Identification of human genome
• Applications to proteomics
• The relationship between the proteome and the genome
• The genome
• Proteins
• From genes to proteins
• Proteomics

CHAPTER 2: PROTEOMIC TECHNOLOGIES

• Laboratory methods used in proteomics
• Separation techniques
• Identification techniques
• Interactions techniques
• Separation techniques
• Identification techniques
• Protein-protein interaction techniques
• Automation
• Pre-fractionation
• Separation
• Identification
• Complete proteomics solutions
• Bioinformatics and databases
• Data Analysis
• Databases
• Laboratory information management systems (LIMS)

CHAPTER 3: PROTEOMIC APPLICATIONS IN DRUG DISCOVERY

• Optimizing the R&D process
• Early selection of efficacious and non-toxic drug targets
• Toxicoproteomics
• Pharmacoproteomics
• Accelerating the discovery of new targets for therapeutic candidates
• Therapeutic proteins
• Protein targets
• Mining the proteome is an alternative approach for drug discovery

CHAPTER 4: PROTEOMIC APPLICATIONS IN CLINICAL TRIAL DESIGN AND PERSONALIZED MEDICINE

• Development of new biomarkers
• Biomarkers as clinical endpoints
• Responders and non-responders
• Patients with adverse reactions
• Patients in different stages of a disease, or other subsets of patients
• Monitor clinical responses in new and comparator drugs - allowing potential strategic alliances
• Patients with disease resistance
• Niche markets
• Application of biomarkers in different therapy areas
• Oncoproteomics
• Application in the diagnosis of: ovarian
• cancer, prostate cancer, breast cancer and
• esophageal cancer
• Neuroproteomics Application in the diagnosis of:
• Alzheimers diseases and amyotrophic lateral sclerosis (ALS)
• Cardioproteomics
• Cardiovascular markers
• Respiratory markers
• Application in organ transplantation
• Post-marketing applications of biomarkers

CHAPTER 5: PHARMACEUTICAL AND PROTEOMIC COMPANY ALLIANCES

• Recent collaborations and alliances of pharmaceutical and proteomic based companies