Epigenetics and MicroRNA Diagnostics/Therapeutics 2008

Table of Contents

Chapter I. Executive Overview of the Space

• What is Epigenetics?
• Epigenetics: An emerging market space
• How Epigenetics modifications affect gene expression
• Cellular pathways disrupted by promoter CpG island hypermethylation
• The various chromatin modifications
• MicroRNAs as an epigenetic controller
• Scope of this report

Chapter II. Biology of Epigenetics

Chapter III. Epigenetics Market Landscape

• Technologies to study epigenetics
• Epigenetics-based therapeutics pipeline
• Primary market survey: Characterizing the epigenetics landscape in qualitative and quantitative terms
• Emerging trends in the epigenetics marketplace
• Profiles of selected epigenetics diagnostics-focused companies

Chapter IV. Market Landscape-microRNA-based Diagnostics and Therapeutics

• microRNAs in Cancer (Types of cancer, microRNA associations)
• microRNAs associated with diseases other than cancer
• Developmental pathways are also regulated by microRNAs, and these may be therapeutics targets
• microRNAs that may regulate cancer-related genes
• microRNA expression profiling in human cancers and its significance
• Primary market survey: Characterizing the microRNA landscape in qualitative and quantitative terms
• Profiles: Selected microRNA diagnostic and therapeutics focused companies [their business focus,

Appendix I. Research Methodology

Appendix II. Glossary of Terms

Appendix III. IP Filings in the microRNA Space

Appendix IV. Selected Events in the Epigenetics Marketplace

Appendix V. HDAC Inhibitors-R&D Pipeline