Security Technologies--Advances in Chemical and Biological Detection Update

1 EXECUTIVE SUMMARY

• Overview
• Overview
• Types of Detectors
• Focus of Research and Development

• Scope and Methodology

• Scope
• Methodology

2 INTRODUCTION TO BIOLOGICAL AND CHEMICAL AGENTS AND DETECTORS

• Survey of Detection Basics
• Reaction Times
• Response Time
• Toxicity
• Deployment and Use of Detectors
• LIDAR Remote Sensing
• DNA and Antibody Methods
• Standoff and Point Detectors
• Demographics and Statistics

Evolving Biological Detection Technologies

• Polymerase Chain Reaction DNA Amplification
• Detectors Based on Antibodies
• Electronic Nose
• Bacterial Chain Reaction
• Future Research Directions

Chemical Agents

• Introduction
• Nerve Agents
• Blister Agents (Vesicants)
• Toxic Industrial Materials (TIMs)

Chemical Detection Technologies

• Introduction
• Point Chemical Detection Technologies
• Ionization/Ion Mobility Spectrometry (IMS)
• Flame Photometry
• Infrared Spectroscopy
• Raman Spectroscopy
• Gas Chromatography
• Electrochemistry
• Surface Acoustic Wave (SAW)
• Photoacoustic IR Spectroscopy
• Photo-ionization Detectors
• Miscellaneous Detection Technologies
• Parameters of a Chemical and Biological Security System
• Level of Toxicity
• First Responder's Detection Equipment
• Recently Deployed Chemical Agent Detection Platforms
• Recently Deployed Chemical Agent Detection Platforms
• Joint Chemical Agent Detector (JCAD)
• Automatic Chemical Agent Detection Alarm (ACADA)
• Improved Chemical Agent Point Detection System (IPDS)
• Joint Service Lightweight Standoff Chemical Agent Detector (JSLSCAD)
• Shipboard Automatic Liquid Agent Detector (SALAD).
• Nonintrusive Detector and the Swept Frequency Acoustic Interferometry (SFAI)
• The Role of First Responders
• Remote Sensing Tool Detects Biological Agents

3 ASSESSMENT OF BIOLOGICAL DETECTION TECHNOLOGIES

• Detection and Identification of Biological Macromolecules
• Nobel Prize: Spectrometric Analyses of Biological Macromolecules
• Fluorescence System To Detect Water Pollutants
• Chemical Sensor Detects Saxitoxin
• Smart Dust Identifies Bioweapons

DNA Methods

• DNA Chip Identifies Pathogens
• DNA/RNA Device Detects Biological Hazards
• New DNA Sensor Passes Litmus Test
• SARS Pathogen Detection and Resequencing Array
• Biosensor Helps in Gene Detection
• Quicker and Economical Gene-Detection Procedure
• Novel DNA Tool Offers Rapid Genetic Analysis of Diseases
• DNA Sensor Detects Biological Weapons

Antibody Methods

• Antibody Library Accelerates Identification Process
• Transistor Detects Cancer
• Drug Detection Gets Smart

Sensors Based on Living Cells

• Sensor Relies on Living Cells To Monitor CB Agent Actions
• Spotting Anthrax Using Spore Detector
• Flow Cytometry

Biological Detection Applications

• Phosphor Reporters
• Automated Biological Agent Testing System (ABATS)

4 ASSESSMENT OF CHEMICAL DETECTION TECHNOLOGIES

• Detectors that Emulate Our Senses
• Security Sniffer Analyzes Gases
• Novel Sensor Measures Astringency
• Remote Multi-spectral Sensor Detects Gas Leaks

Detection of Metal Contamination

• Novel Technique Detects Plutonium Contamination in Food
• Device Detects Heavy Metals

Micro- and Nano- Sensors

• Nanosensor for Accurate Chemical Analysis
• Low-Cost Spectrometer Shows Excellent Efficiency
• Novel Biochip To Screen Drugs
• Tiny Sensors Are Good for Multiple Applications

Detection of Nerve Agents

• Technique Detects Nerve Agent's Swift Decay
• Thin-Film Sensor Detects Chemical Nerve Agents

Detection of Explosives and Landmines

• Lasers Detect Traces of Gases
• System Detects TNT
• Laser Detection Assists in Mine Clearing
• Chemical Signatures of TNT-Filled Land Mines
• Developing Polymers for Explosives Sensors

Design and Manufacturing Innovations

• Hermetically Sealed Chemical Sensor Is Inexpensive
• Underground Gas Detection Made Simple

5 ENVIRONMENTAL SAMPLING AND MONITORING

• Protection of Water Resources
• Chip Detects Pollutants in Wastewater Treatment Plants
• Bioterrorism and Waterborne Pathogens
• Novel Method Will Detect Contaminants in Water
• Network of Sensors Monitors Contaminants in Water

Air Sampling and Analysis for CB Agents

• Air Sampling Technology
• Combining MALDI and Aerosol Time-of-Flight Mass Spectrometry

New Directions in Environmental Monitoring

• System Detects Wildfire Even in Small Traces
• Detecting Metal Traces
• Device Detects Pollutants Electrically
• Novel Colorimetric Sensor Detects Environmental Contaminants

Long-term Vigilance

• General Environmental Monitoring for Homeland Security
• Air Monitoring

6 PORTAL SECURITY

• Terahertz Backscatter
• Technology To Detect Hidden Weapons
• Advanced Camera Employs Terahertz Waves

Inspecting with X-ray Backscatter

• Introduction
• Airport Screeners May Get X-ray Vision
• Cosmic Particles Help in Weapons Detection

Satellite Imaging

• New US Commercial Remote Sensing Policy Provides Direction and Challenges
• Remote Sensing Tool Detects Biological Agents

E-Nose and E-Tongue

E-Nose Proves Economical

• Detecting Microbes with an Electronic Tongue

Radiation Detection

• New Technique To Detect Radiation
• The Reality of the Dreaded Dirty Bomb

7 MARKET ASPECTS OF DETECTION

• Introduction
• Development of Biological Detectors
• Small to Medium Size Metropolitan Areas

Detection of Pathogens

• DNA Probes
• Evolving Testing Technologies Biowarfare Agents

Potential Market for Chemical and Biological Detector Systems

• How Many Are Needed
• US Federal Budget Activates New and Old Companies
• Can We Meet the Challenge

8 COMPANIES AND THEIR PRODUCTS

• Companies and their Products
• Companies: Adams Electronics International Ltd. To CombiMatrix
• Companies: EAI Corporation to Intellitec
• Companies: Jaycor to Response Equipment Company
• Companies: Schwartz Electro Optics to V.F. Warner and Assoc. Inc.
• Appendices
• Research and Development Contacts
• Biosafety Levels
• Laboratory Response Network
• Acronyms
• US Patents Related to Chemical and Biological Detection

9 TECHNICAL INSIGHTS 2003 SCIENCE AND TECHNOLOGY AWARDS

• Technology Innovation
• Award Description
• Award Recipient

Technology Leadership

• Award Description
• Award Recipient