Stem Cells--Emerging Markets and Growth Opportunities

Table Of Contents

1 EXECUTIVE SUMMARY

Introduction

1.Introduction

2.Embryonic Vs. Adult Stem Cells

Key Findings

1.International Developments

2.Market and Applications Overview

3.Research Methodology

2 INTRODUCTION

Embryonic and Adult Stem Cells

1.Introduction

2.Embryonic Stem Cells

3.Political Debate

4. Cloning: Therapeutic Vs. Reproductive

5.Adult Stem Cells

Potential Applications for Stem Cell Therapies

1.Gene Therapy/Tissue Engineering

2.Neurological Therapies

3.Bone and Cartilage; Repair and Regeneration

3 MARKET ANALYSIS

Market Forecast and Sectors Affected by Stem Cell Therapeutics

1.Market Forecast

2.Alzheimer's; Cancer; Heart Disease

3.Wounds; Burns; and Skin Ulcers

4.Spinal Repair Therapies

5.Tissue Engineering

6.Bone Implants and Cartilage Regeneration

7.Organ Transplantation

8.Breast Cancer Therapies

9.Diabetes Therapies

10.New Heart Attack Therapeutics

11.New Products Will Face Competition

12.Gene Therapy

13.International Efforts

Market Drivers and Opportunities

1.R&D Funding

2.Government Funding/Population Issues/Partnerships

4 MARKET AND TECHNOLOGY CHALLENGES AND BARRIERS

Introduction

1.Introduction

2.Culture Difficulties

Key Challenges and Barriers

1.Key Restrictions

2.The Stem Cell Debates: Political and Biological

3.Quality Control

4.Other Challenges

5 STEM CELL TECHNOLOGIES

International Efforts

1.Scotland: Stem Cell Osteoblasts Could Help Osteoporosis

2.Germany: Patient's Own Stem Cells Restore Damaged Heart Muscle

3.Japan: Artificial Eyeballs and Other Research

4.Canada: So Simple? Stem Cells Regenerate Injured Mouse Pancreas

5.Israel: Human Heart Tissue Generated from Embryonic Stem Cells

6.Korea: Human Embryo Cloned

7.China: Stem Cells from Human-Rabbit Hybrid Embryo

8.Sweden Funds Stem Cell Research

9.UK: International Human Stem Cell Project

10. India/Switzerland

Growing; Storing; and Analyzing Stem Cells

1.Rare Adult Stem Cells As Multipotent As Embryonic?

2.Adult Stem Cells Might Not Trans-Differentiate after All

3.But Then Again�c

4.Serum-Free; Mouse-Cell Free Culture System

5.Another Serum-Free; Mouse-Cell Free Culture System

6.Private Funds Yield New Embryonic Lines

7.Human ESCs Stable in Culture over Long Time

8.Embryonic Skin Cells Committed at an Early Age

9.Blood Cells from ESCs May Protect against Transplant Rejection

10.Stem Cell-Specific Genes Analyzed

11.Stem-Cell Factor and Flt3-Ligand for Stem Cell Growth

12.One-Cell Genetics Lab-On-Chip

13.Cytometry Probes Effect of HIV on Stem Cells

14.New Freezing Method Keeps Stem Cells Viable

Scaffolds for Tissue Engineering

1.Temperature-Sensitive Hydrogel for Joint Repair

2.Fibrin/Polymer Matrix Slows Growth Factor Dissipation

3.Biorubber Makes Good Scaffold for Stem Cell Growth

4.A Collagen Bandage

5.Molecule Mimics Tissue Nanostructure for Scaffolds

6.Stem Cells + Scaffold + Growth Factors = New Tissues

Tissue Repair and Regeneration

1.Neurological Therapies

2.Cardiovascular Therapies

3.Bone and Cartilage

4.Diabetes

5.Cancer

6.Miscellaneous

Dedifferentiation

1.Regeneration by Dedifferentiation: No Stem Cells Needed?

2.More Dedifferentiation: Chemical Turns Muscle Cells back into Stem Cells

Engineering Whole Tissues

1.Functioning Liver Tissue Grown in a Bioreactor

2.Tissue-Engineered Joint from Stem Cells

3.Tissues Derived from Nuclear Transplantation Avoid Immune Rejection

4.Engineered Tissue Goes Chomp

5.CAD/CAM Meets Bioassembly of Live Tissue

Ex Vivo Gene Therapy

1.Stem Cell Gene Therapy for Blood Disorders

2.Gene Therapy Corrects Blistering Skin Disorder in Mice

3.Telomerase Gene Extends Lifespan of Adult Marrow Stem Cells

4.Mesenchymal Stem Cells Target Tumors

5.RNA Interference Tunes Gene Activity in Stem Cells

6.Cells of Knockout Pigs Acceptable to Human Immune System

7.Adult Stem Cells As Natural Gene Therapy

6 PATENTS AND CONTACT DETAILS

Patents

1.Patents - I

2.Patents - II

3.Patents - III

4.Patents - IV

Contact Details

1.Contact Details

7 FROST & SULLIVAN 2004 SCIENCE AND TECHNOLOGY AWARDS

Technology Innovation Award

1.Awards Description

2.Award Recipient

Technology Leadership Award

1.Award Description

2.Award Recipient

8 DECISION SUPPORT TABLES

Prevalence of Arthritis (Millions)

1.Worldwide Prevalence of Arthritis by Country (Millions)

Cardiovascular Prevalence as Percentage of Total Population

1.Cardiovascular Prevalence Per Country as Percentage of Total Population

Cardiovascular Prevalence (Millions)

1.Cardiovascular Disease Prevalence Per Country(Millions)

Number of Heart Transplants

1.Number of Heart Transplants Per Country

Number of Kidney Transplants

1.Number of Kidney Transplants Per Country