Biotechnology Up-Stream and Down-Stream Processing Technology Analysis

Table of Contents

1 EXECUTIVE SUMMARY

• Introduction
  • Introduction
  • Technology Primer
• Scope and Methodology
  • Scope
  • Methodology

2 TECHNOLOGY AND APPLICATIONS VIEWPOINT

• Application Analysis and Trends
  • Microbial Fermentation
  • Glycomics and Biopharmaceuticals
  • Diagnostic Applications
  • Therapeutic Applications
  • Biopolymers
  • Cell Culture
  • Sensors in Biotechnology Processing
  • Other Applications
• Industry Trends and Assessment
  • Industry Trends
  • Mergers and Acquisitions
  • Regulatory Issues
  • Funding Analysis

3 ASSESSMENT OF INNOVATIONS IN UPSTREAM PROCESSING: NORTH AMERICA ASIA AND EUROPE

• Antibodies
  • Enhanced Genetic Evolution--USA
  • Phage Display and Humanized Antibodies--USA
  • RNA Synthesis and Delivery of Antibodies--USA
  • Humanized Antibodies from Yeast--USA
  • Comparing Polyclonal Humanized Antibodies with Monoclonals--USA
  • High-Throughput High-Diversity Generation of Antibody Platform--UK
  • Fucose Increases Antibody-Dependent Cellular Cytotoxicity--Japan
  • Production of Fully Human Antibodies through Human Combinatorial Antibody Libraries--Germany
  • Phage Display Technique Targets Bacterial Haptens--UK
  • Other Companies
• Vaccines
  • Flu Vaccine from Cell Culture Instead of Eggs--USA
  • Potato Vaccine for Hepatitis B--USA
• Antibiotics
  • Antimicrobial Peptide from Fungus Kills Resistant Infections--Denmark
  • Metabolic Pathway Engineering Simplifies Antibiotic Preparation--Netherlands
• Other Biopharmaceuticals
  • Improved Recombinant Interferon--USA
  • Bioconversion for Production of Chiral Compounds--Japan
  • Biocatalysis and Metabolic Engineering for Vitamin and Nutrient Production--Germany
  • Modified E. Coli Make Human Glycoproteins--USA
• Enzymes
  • Fungal Genome Sequence for Better Enzymes--USA
  • Directed Evolution: Increased Mutation Rate Yields Enhanced Enzymes--USA
  • Solid-Phase Massively-Parallel Screening System for Improved Enzyme Mutants--USA
  • Rearranging DNA to Improve Variants--USA
  • Genetic Engineering to Boost Xylanase Output--Canada
• Plants and Algae
  • Lack of Financing Shuts down Large-Scale Biology--USA
  • Transgenic Duckweed for Protein Manufacture--USA
  • Tobacco Plant-Based Monoclonal Antibodies against Tumor Cells--USA
  • Cotton Roots Produce Gossypol Antibiotic--USA
  • Metabolomics Changes Plants to Chemical Factories--USA
  • Insulin Production in Plants--Canada
  • Polysaccharide from Immobilized Callus Cultures--India
• Transgenic Animals
  • Human Antibodies and Other Therapeutic Proteins from Chicken Eggs--USA
  • Transgenic Mice for Production of Fully Human Antibodies--USA
  • Human Antithrombin from Transgenic Goat Milk--USA
  • Transgenic Rabbits Produce C1 Inhibitor for Hereditary Angioedema--Spain
• Biopolymers
  • Stabilized Gene Transfer for Producing Recombinant PHA--USA
  • Yeast Produces Tailor-Made PHA Polymers--USA
  • Limiting Nitrogen Boosts Bacterial PHA Synthesis--Ireland
• Bioreactors and Fermenters
  • Eliminating Cryptic Plasmid Improves Fermentation--USA
  • Microreactor Regenerates Enzyme Cofactors--USA
  • Boost Cobalamin to Improve Fermentation Microbes--USA
  • Novel Two-Phase Fermenter Process--Netherlands
  • Tubular versus Bubble Column Photobioreactors--Spain
• Cell Culture
  • Stable Analog of Poly D-Lysine for Fastidious Cells--USA
  • Nanofiber-Based Cell-Culture Platform--USA
  • Single Cell from Embryo Can Generate Stem Cell Lines--USA
  • Feeder-Free Derivation of Embryonic Stem Cells--USA
  • Artificial Intelligence Controls Cell-Culture Parameters--Finland
  • Special Culture Dish for Both Long-Term Cell Culture and Imaging--Germany
  • Additional Companies
  • Growing Bone Cells on Carbon Nanotubes--USA
  • 3D Capillary Channeled Fibers for Scaffolds--USA
• Sensors and Detectors
  • Universal Detector for HPLC--USA
  • CCD Technology-Based Image Sensors for Process Control--UK
  • Augmenting Cell Culture Optimization Using Optical Sensors--USA
  • Biosensor Dye Aids Viewing Proteins in Live Cells--USA
  • Biocompatible Poly (Dimethylsiloxane) Coatings for Sensors and Microfluidic Devices--USA
  • Fiber-Optic Sensor Measures pH--USA
  • Novel Ultrasonic Sensor for In Situ Detection of Protein Fouling--China

4 ASSESSMENT OF INNOVATIONS IN DOWNSTREAM PROCESSING: NORTH AMERICA ASIA AND EUROPE

• Nucleic Acid Purification
  • RNA Manufacturing In cGMP Facility--USA
  • ChargeSwitch Technology to Purify Nucleic Acids--USA
  • Convoluted Polymer-Coated Beads for High-Yield mRNA Purification--Netherlands
  • Column To Purify Plasmid DNA--Slovenia
• Chromatography
  • High Speed Ultraperformance Liquid Chromatography (UPLC)--USA
  • Removal of Abundant Proteins Allows Purification of Low-Abundance Proteins--USA
  • Liquid-Liquid Counter-Current Chromatography Saves Time and Money--UK
  • Molecularly Imprinted Polymers for Large-Scale Specific Separations--Sweden
  • Additional Companies
• Membrane and Filter Separations
  • Nanofilter Traps Micron-Sized Particles--USA
  • Portfolio of Specialized Filters--USA
  • Membrane Processing Improves Enzyme Production Pharmaceutical Applications--Sweden
  • Multichannel Membranes for Microfiltration--France
  • Additional Companies
• Manufacture and Scale-Up
  • Large-Scale Process for Ricin Vaccine Production--USA
  • True Micro-Bioreactor Scale-Up--USA
  • Step-Wise Scale-Up of Pharma Protein Production Up to 25000 Liters--Netherlands
  • Additional Companies
• Process Design and Management Software
  • Enhancements to Execution Software--USA
  • Software for Enhanced Asset Performance--USA
  • Software Portfolio for Process Manufacturers--USA
  • Computer Modeling Platform Predicts Cellular Metabolism and Behavior--USA

5 TECHNOLOGY ADOPTION FACTOR ANALYSIS

• Technology Development Restraints And Market Challenges
  • Technology Restraints
  • Technology Challenges
  • Competing Technologies
• Technology Adoption Drivers and Benefits
  • Adoption Drivers
  • Technology Benefits

6 DATABASE OF KEY INDUSTRY PARTICIPANTS AND SELECTED PATENTS

• Patents
  • US Patents
  • International Patents
• Key Industry Participants
  • Companies
  • Universities

7 FROST & SULLIVAN 2006 SCIENCE & TECHNOLOGY AWARDS

• Technology Leadership Award
  • Award Description
  • Award Recipient
• Technology Innovation Award
  • Award Description
  • Award Recipient
• Excellence in Technology Award
  • Award Description
  • Award Recipient

8 DECISION SUPPORT DATABASE

• Database Tables
  • Biotech Companies (1999-2006)
  • Biotech Employees (1999-2006)
  • Biotech Private Investment (1999-2006)
  • EPO Biotech Patents (1999-2006)
  • Government Biotech R&D Investment (1999-2006)
  • USPTO Biotech Patents (1999-2006)
  • Percent Government Biotech Investment (1999-2006)