Abstract
Developing High Throughput Technologies for Protein Analysis
As most drug targets are proteins, there is a vested interest in high
throughput technologies for proteins. Proteins are 3D fragile structures
unlike DNA chips, so concept of surface chemistry and density requirements
need to be evaluated before plunging into chip manufacturing.
Demand for Tools which Promise to Hasten the Drug Discovery Process
The pharmaceutical industry is now under tremendous pressure from dwindling
drug pipelines, no recent launch of potential blockbuster drugs and expiry of
patents for the present blockbuster drugs. Pharmaceutical companies are now
looking for tools that would hasten the drug discovery process and improve
productivity. Any tool or technology that has been found to have these
benefits is being actively pursued.
Automation Not Living Up to the Expectations
Technologies such as HTS as well as automation of the drug discovery process
have not lead to any significant increase in the drug pipelines. The
assumption of increasing the probability of a successful drug discovery by
screening more number of compounds has not yielded results. So the goal is to
make these technologies yield maximum output.
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