Advances in Biomarkers

Table of Contents

1 EXECUTIVE SUMMARY

• Scope and Methodology
  • Scope and Segmentation of the Research Service
  • Research Methodology
• Overview of Biomarkers
  • Introduction to Biomarkers
  • Applications of Biomarkers
  • Technology Platform for Biomarker Discovery

2 ASSESSMENT OF ENABLING TECHNOLOGIES FOR BIOMARKER DETECTION

• Noteworthy Innovations in Companies and Universities
  • MASStermind Approach for Biomarker Discovery and Validation
  • Reverse-Capture Autoantibody Microarray Platform for Profiling Prostate Cancer Biomarkers
  • Differential Methylation Hybridization Platform for Drug Response Prediction
  • Protein Detection Made Easy with a New Microchip System
  • Software Solution for Analysis of Microarray Expression and ArrayCGH Experiments
  • Research Grade Mass Spectrometer for Biomarker Recognition
  • Microfluidics-On-Chip Synthesis Platform for Biomarker Discovery
  • Bioinformatics Solution for 2D Image Analysis
  • Isobaric Mass Tags To Heighten MS Performance
  • Bioinformatics Database as a Repository of Biomarkers
  • Imaging Science and Biomarker Development at ISBE
  • Competitive Template PCR with a Twist
  • Chip-Based Technology for Detecting Biomarkers
  • Peptidomics In Biomarker Discovery
• Drivers and Challenges
  • Drivers
  • Challenges

3 ASSESSMENT OF BIOMARKER APPLICATIONS

• Noteworthy Innovations in Companies and Universities
  • Biomarker-Based Test for Detection of Tuberculosis--Australia
  • Proteomics Technology Platform for Target Identification and Predictive Medicine
  • Identification of Plasma Biomarkers for Statin-Induced Myopathy
  • Water Diffusion-Based Biomarker for Breast Cancer
  • Non-Invasive Method to Assess Human Embryo Viability Using Metabolomic Profiling
  • Protein Biomarkers Detected for Ischaemic Liver Injury
  • DNA Methylation Technology for Diagnostic and Prognostic Tests
  • SmartAssays for Early Detection of Damage to Kidney Liver or Pancreas
  • CLIA-Approved Test to Predict Breast Cancer Recurrence
  • Biomarker Development for Traumatic Brain Injury
  • Power3' s Foray into Biomarker Discovery and Development
  • FDA-Approved Prognostic Test For Breast Cancer
  • Biomarker to Detect Cardiovascular Disease at an Early Stage
• Drivers And Challenges
  • Drivers
  • Challenges

4 TECHNOLOGY ADOPTION FACTOR ANALYSIS

• Competitive Landscape
  • Key Findings in the Biomarker Industry
  • Geographic Trend Analysis
• Industry Insights
  • Biomarker Analysis by Therapeutic Areas
  • Analysis of Biomarkers in Clinical Trials
  • SWOT Analysis

5 PATENTS AND DATABASE OF KEY INDUSTRY PARTICIPANTS

• Patents
  • Industry Patents
  • Academic Patents
• Key Participants
  • Companies
  • Universities

6 DECISION SUPPORT DATABASE

• Database Tables
  • Global R&D Expenditure for Biotechnology (2002-2012)
  • Percent Government R&D Investment in Biotechnology (2002-2012)
  • Global Pharmaceutical R&D Expenditure (2002-2012)
  • Global Percentage Pharmaceutical R&D Expenditure (2002-2012)