Microarray Markets

Table of Contents

1. Overview 4

• 1.1 Statement of Report 4
• 1.2 About This Report 4
• 1.3 Scope of the Report 5
• 1.4 Objectives 6
• 1.5 Methodology 6
• 1.6 Executive Summary 7

2. Overview of Microarrays 9

• 2.1 History of Microarrays 9
• 2.2 Genomics and Proteomics 10
• 2.2.1 Genetic Variability and Disease 11
• 2.3 General Theory of Microarrays 11
• 2.4 DNA Microarrays 12
• 2.5 Protein Microarrays 14
• 2.6 Tissue Microarrays 15

3. DNA Microarrays 17

• 3.1 Advantages and Drivers 17
• 3.2 Limitations and Barriers to Commercialization 18
• 3.3 DNA Microarray Technology Platforms 19
  • 3.3.1 Reasons Why Researchers Utilize DNA Microarrays 23
  • 3.3.2 Factors for Difficulties Applying DNA Microarrays Technology 23
• 3.4 Key Attributes of DNA Microarray Software 24
• 3.5 Applications 24
• 3.6 Future Directions for DNA Microarray Technology 29
  • 3.6.1 High-Throughput Array Technology 29
  • 3.6.2 Emerging Microarray Trends 31
  • 3.6.3 Emerging Microarray Applications 31
  • 3.6.4 Key Points for Developing Microarray Based Applications 32

4. Protein Microarrays 33

• 4.1 Critical Factors for Microarray Content 33
• 4.2 Key Findings on Use of Microarrays 33
• 4.3 Advantages and Drivers 34
• 4.4 Limitations and Barriers to Commercialization 36
• 4.5 Key Experimental Parameters of Protein Microarray Technology for Current and Future Users 38
• 4.6 Reasons Why Researchers Utilize Protein Microarrays 39
• 4.7 Factors for Adoption of Protein Microarrays Technology 39
• 4.8 Top Suppliers of Protein Microarray Slides and Products 40
• 4.9 Factors that Influence Sale Decisions 40
• 4.10 Future Innovations in Protein Microarray Technology 40

5. Current DNA Microarrays 41

• 5.1 Key Players 41
• 5.2 High Growth Applications 43
  • 5.2.1 Microarray-Based Commercial Genotyping Activity 43
  • 5.2.2 Location Analysis 43
• 5.3 Future Innovations in DNA Microarray Technology 43

6. Current Protein Microarrays 45

• 6.1 Protein Profiling Microarrays-Antibody Arrays 45
• 6.2 Protein Profiling Microarrays-Reverse Phase Microarrays 47
• 6.3 Multiplex Sandwich Microarrays-Planar 48
• 6.4 Multiplex Sandwich Immunoassays-Bead Based 50
• 6.5 Microarrays for Protein Function Studies 52
• 6.6 High Growth Applications 54
  • 6.6.1 Cytokine Arrays 54
  • 6.6.2 Whole Proteome Arrays 54
  • 6.6.3 Microarray-Based Commercial Genotyping Activity 54
    • 6.6.3.1 Microarray-Based Genotyping Applications 54
    • 6.6.3.2 Microbial Applications 55
    • 6.6.3.3 The Market for Microbial Genotyping Products 56
    • 6.6.3.4 Comparative Genomic Hybridization 56
  • 6.6.4 ChIP-on-Chip Analysis 57

7. Technology 59

• 7.1 Production of Microarrays 59
• 7.2 2-D Versus 3-D Technology 61
• 7.3 Substrates and Surface Chemistries 61
• 7.4 Detection Methods 63
• 7.5 Instruments 63
• 7.6 Data Management and Informatics in Gene Expression 64

8. Applications 65

• 8.1 DNA Microarrays in Gene Expression 65
• 8.2 DNA Microarrays in SNP Analysis 68
• 8.3 DNA Microarrays in Cancer 69
• 8.4 Protein Expression 69
  • 8.4.1 Cytokine Applications 70
  • 8.4.2 Protein Function 70
  • 8.4.3 Protein-Protein Interactions 71
• 8.5 Target /Biomarker Discovery 71
• 8.6 Drug Discovery and Development (Gene and Protein Microarrays) 72
• 8.7 Clinical Diagnostics (Gene and Protein Microarrays) 72
• 8.8 RNA Microarrays 73
• 8.9 Oligo Microarrays 73
• 8.10 Yeast Microarrays 74
• 8.11 Antibody Arrays 74

9. The Commercial Opportunity for Microarrays 75

• 9.1 Market Drivers for Microarrays 75
• 9.2 Market Restraints for Microarrays 75
• 9.3 Key Players 76
• 9.4 Market Size, Strategic Trends and Competitive Landscape for Protein Arrays 79
• 9.5 Marketing and Distribution 81
• 9.6 Protein Arrays Market Analysis 82
• 9.7 Genes Associated with Major Diseases 83
• 9.8 Software and Data Analysis 83
  • 9.8.1 Supplier of DNA Microarray Analysis Software 84
  • 9.8.2 Satisfaction with Software Features 84
  • 9.8.3 Satisfaction with Software 84
  • 9.8.4 Supplier Factors in Software Purchase Decision 84
  • 9.8.5 Suppliers' Role in Improving Data Sharing for DNA Microarrays 84

10. Legal Aspects of Commercialization of Protein Arrays 85

11. Company Profiles 87

Appendix 1: Microarray Milestones 124

LIST OF FIGURES

• Figure 5.1: Company Market Shares 41
• Figure 8.1: Overall Market Size by Application, 2005 66
• Figure 8.2: Source of Variation in Microarray Data 73

LIST OF TABLES

• Table 3.1: Source of DNA Microarrays in Research Use 17
• Table 3.2: Microarray Market Drivers 17
• Table 3.3: Microarray Market Barriers 18
• Table 3.4: Unit Pricing of DNA Microarrays, 2000-2010 18
• Table 3.5: Steps in the Design and Implementation of a DNA Microarray Experiment 20
• Table 3.6: The Main Features of Some Hybridization Microarray Formats Currently Available 21
• Table 3.7: Microarray Applications 24
• Table 3.8: List of DNA Array Manufacturers 26
• Table 4.1: Critical Factors for Microarray Content 33
• Table 4.2: Top Three Suppliers of Treated Protein Microarray Surfaces for Self-Printing 40
• Table 4.3: Top Suppliers of Commercially Available Protein Microarrays 40
• Table 4.4: Top Suppliers of Protein Microarray Readers 40
• Table 5.1: Affymetrix Sales of Probe Arrays, 2000-2005 42
• Table 5.2: Affymetrix Total Product Sales, 1999-2005 42
• Table 5.3: Affymetrix Instrument Sales, 2000-2005 42
• Table 6.1: Microarray Genetic Testing 54
• Table 6.2: ChIP-on-Chip Microarray Market Size Projections, 2005-2011 57
• Table 8.1: Applications of Biochips by Class 65
• Table 8.2: Diagnostics Microarray Market Size Projections, 2005-2011 66
• Table 8.3: HTS Microarray Market Size Projections, 2005-2011 66
• Table 8.4: Pharmacogenomics Microarray Market Size Projections, 2005-2011 67
• Table 8.5: Toxicology Screening Microarray Market Size Projections, 2005-2011 67
• Table 8.6: Expression Profiling Microarray Market Size Projections, 2005-2011 67
• Table 9.1: Market Share of Microarray Products, 2004 76
• Table 9.2: Affymetrix Product Sales 77
• Table 9.3: Agilent' s Net Revenue by Business Segment, 2002, 2003 and 2004 77
• Table 9.4: Leading Microarray Companies 78
• Table 9.5: Worldwide Microarray Market Size, 2004-2011 79
• Table 9.6: Microarray Market Share by Technology Type 79
• Table 9.7: DNA Microarray U.S. Market Size, 2005-2011 80
• Table 9.8: DNA Microarray Worldwide Market Size, 2002-2011 80
• Table 9.9: Biochip Market by Usage, 2003 and 2007 80