DNA Sequencing and PCR Markets

Table of Contents

• 1. Overview
  • 1.1 Statement of Report
  • 1.2 About This Report
  • 1.3 Scope of the Report
  • 1.4 Methodology
  • 1.5 Executive Summary
• 2. Introduction to DNA Sequencing and Amplification and PCR Technology
  • 2.1 Science Overview: Introduction to DNA
    • 2.1.1 DNA Sequencing and PCR Applications Space
    • 2.1.2 Proteomics
    • 2.1.3 Products for the Genomics Market
  • 2.2 The Impact of the Human Genome Project on Molecular Biology
  • 2.3 Impact of DNA Sequencing Techniques on Biotechnology, Pharmaceutical and Healthcare Industries
  • 2.4 Molecular Diagnostics in the Post-genomic Era-The Role of SNPs
  • 2.5 Advances in Molecular Diagnostic Technologies
  • 2.6 The Use of PCR Technology
  • 2.7 Genetic Variability and Disease
• 3. Market Analysis of PCR and DNA Sequencing Product Market
  • 3.1 Overview of the Sequencing and Amplification Market
    • 3.1.1 Highlights of DNA Sequencing Market
    • 3.1.2 Genomic Analysis Market Development
    • 3.1.3 Leading U.S. and Canadian Companies Offering Sequencing Technology Platforms
    • 3.1.4 Competition
    • 3.1.5 Markets for DNA Sequencing
    • 3.1.6 Market Opportunity
    • 3.1.7 Market Dynamics
    • 3.1.8 Overview of Current DNA Sequencing Technology Platforms and Players
    • 3.1.9 Limitations of Current Sequencing Technologies
    • 3.1.10 Overview of the Life Science Marketplace
    • 3.1.11 Research Laboratories
      • 3.1.11.1 Market Share
  • 3.2 Paradigm Shift in Drug Discovery and Development
    • 3.2.1 Systems Biology and the Need for More Effective Tools
    • 3.2.2 Molecular Medicine and the New Therapeutics
    • 3.2.3 Pharmacogenomics Using Genotyping and Phenotyping Clinical Biomarkers
    • 3.2.4 The Market
  • 3.3 Detection of Amplified DNA
    • 3.3.1 Nucleic Acid Amplification Methods
    • 3.3.2 Amplification of Refractory Mutation System (ARMS)
  • 3.4 DNA Reagent Applications Market Share and Key Players
    • 3.4.1 Product Description
      • 3.4.1.1 Pricing
  • 3.5 PCR/DNA Testing Market Analysis
    • 3.5.1 Nucleic Acid-Amplification and Detection Systems: How Big a Market?
    • 3.5.2 Market Size 2004-2010 and Growth Projections in DNA Amplification Instrumentation
      • 3.5.2.1 U.S. Market
      • 3.5.2.2 European Market
    • 3.5.3 Market Share of Key Players in DNA Amplification
  • 3.6 The Drivers of the Biotech Industry
    • 3.6.1 Isolation of DNA for PCR Profiling
    • 3.6.2 Analysis by PCR-Based DNA Typing
    • 3.6.3 Rapid Isolation of DNA for RFLP and PCR
    • 3.6.4 DNA for PCR-STR Typing
  • 3.7 Biotechnology Instrumentation Outlook
    • 3.7.1 Products for the Genomics Market
    • 3.7.2 Genetic Analysis Products
• 4. Use of PCR and DNA Amplification Products
  • 4.1 PCR Components
    • 4.1.1 Primers for PCR
    • 4.1.2 Equipment for PCR
  • 4.2 Sources of DNA for PCR
  • 4.3 PCR Primer Sequence
  • 4.4 Thermostable DNA Polymerases
  • 4.5 PCR Protocols
  • 4.6 Microfluidic Automated DNA Analysis Using PCR
• 5. Technical Trends in PCR
  • 5.1 Practical Applications of PCR
    • 5.1.1 Overview
  • 5.2 Quality Control Issues in PCR
  • 5.3 Determining Length of cDNA Product
    • 5.3.1 Direct Signal Amplification Using the Invader Assay
    • 5.3.2 Biosensor Technologies
      • 5.3.2.1 DNA Hybridization Biosensor Chips
      • 5.3.2.2 PNA-Based Biosensors
  • 5.4 Novel Nucleic Acid Amplification Techniques
  • 5.5 Microplate Readers
  • 5.6 Genotyping Methods
    • 5.6.1 Use of DNA Sequencers
      • 5.6.1.1 Capillary-Based Sequencers
      • 5.6.1.2 Pyrosequencing
    • 5.6.2 Use of Microarrays
  • 5.7 RiboMaker Detection System
  • 5.8 RNA Isolation Kits
  • 5.9 Nucleic Acid Sample Prep Platforms
  • 5.10 DNA Microarrays
    • 5.10.1 The Technique
    • 5.10.2 The Market
    • 5.10.3 Gene Expression Monitoring Arrays
  • 5.11 Emerging Markets of DNA Arrays
  • 5.12 Alternatives to PCR Amplification
    • 5.12.1 Locked Nucleic Acids (LNAs)
    • 5.12.2 Multiplexed Nuclease-Protection Assay and ArrayPlate
• 6. Corporate Directory
  • 6.1 Abbott Laboratories
  • 6.2 Affymetrix
  • 6.3 Agilent Technologies
  • 6.4 AgriGen Biotech Pty
  • 6.5 GE Healthcare
  • 6.6 Applera Applied Biosystems
  • 6.7 Avesthagen Gengraine Technologies, Pvt.
  • 6.8 Bayer Corporation
  • 6.9 BD Biosciences
  • 6.10 Beckman Coulter
  • 6.11 BGI Life Tech
  • 6.12 bioMérieux
  • 6.13 Bioneer
  • 6.14 Bio-Rad Laboratories
  • 6.15 BioTrove
  • 6.16 Caliper LifeSciences
  • 6.17 Cepheid
  • 6.18 Cogenics (A subsidiary of Clinical Data)
  • 6.19 CombiMatrix Corporation
  • 6.20 Commonwealth Biotechnologies
  • 6.21 Complete Genomics
  • 6.22 CuraGen Corporation
  • 6.23 Cytocell
  • 6.24 Dako A/S
  • 6.25 DiaDexus
  • 6.26 DNA LandMarks
  • 6.27 DNAVision
  • 6.28 Enzo Biochem
  • 6.29 Epicentre
  • 6.30 Eppendorf AG
  • 6.31 Eurofins Medigenomix
  • 6.32 Exiqon
  • 6.33 Febit Biomed
  • 6.34 Geneart AG
  • 6.35 GeneticTechnologies Limited
  • 6.36 GeneWorks
  • 6.37 Genisphere
  • 6.38 Genizon BioSciences
  • 6.39 Genovoxx
  • 6.40 Gen-Probe
  • 6.41 Genset
  • 6.42 Genta
  • 6.43 Genzyme
  • 6.44 GVK BIO
  • 6.45 Hamilton Thorne Biosciences
  • 6.46 Helicos BioSciences Corporation
  • 6.47 High Throughput Genomics
  • 6.48 Hokkaido System Science
  • 6.49 Hy Laboratories
  • 6.50 Illumina
  • 6.51 Incyte Corporation
  • 6.52 Integrated DNA Technologies
  • 6.53 Invitrogen
  • 6.54 Inqaba Biotechnical Industries
  • 6.55 Johnson & Johnson
  • 6.56 Kreatech Holding BV
  • 6.57 LI-COR
  • 6.58 Sygnis Pharma AG
  • 6.59 Lucigen
  • 6.60 Luminex Corporation
  • 6.61 Meridian Biosciences
  • 6.62 Microchip Biotechnologies
  • 6.63 Microsynth AG
  • 6.64 MilleGen SA
  • 6.65 Millennium Pharmaceuticals
  • 6.66 MWG Biotech AG
  • 6.67 Myriad Genetics
  • 6.68 Nanogen
  • 6.69 Nanosys
  • 6.70 Nymox
  • 6.71 Ocimum Biosolutions
  • 6.72 Orchid Cellmark
  • 6.73 Ostex
  • 6.74 Pacific Biosciences
  • 6.75 PamGene
  • 6.76 Perlegen Sciences
  • 6.77 PPD
  • 6.78 PPGx
  • 6.79 PrimmBiotech
  • 6.80 Promega
  • 6.81 Biotage
  • 6.82 QIAGEN
  • 6.83 Quidel
  • 6.84 Research Biolabs Pte
  • 6.85 Roche Diagnostics
  • 6.86 Shanghai Sangon Biological Engineering Technology & Services Co.
  • 6.87 Saturn Biotech
  • 6.88 Sequenom
  • 6.89 Sequetech
  • 6.90 Shimadzu Biotech
  • 6.91 Siemens AG
  • 6.92 Tepnel Life Sciences
  • 6.93 Third Wave Technologies
  • 6.94 Visible Genetics
  • 6.95 VisiGen Biotechnologies
  • 6.96 Vysis
  • 6.97 Wellcome Trust Sanger Institute
  • 6.98 ZS Genetics
• 7. Market Trends and Forecasts
  • 7.1 Market Dynamics
  • 7.2 Future Considerations for Molecular Diagnostics
  • 7.3 How Genomics is Transforming Pharmaceutical R&D
  • 7.4 Cancer Markers
  • 7.5 NAT and Personalized Medicine
  • 7.6 Three Growth Areas of Molecular Diagnostics
  • 7.7 RNA Detection
  • 7.8 Ramification Amplification Method
  • 7.9 Invader Assays/Third Wave Technologies
  • 7.10 Molecular Beacons
• 8. Major Product Innovations/Launches in DNA Sequencing Industry
  • 8.1 Major Product Innovations/Launches in DNA Sequencing Industry
  • 8.2 Major Activities in DNA Sequencing Industry

LIST OF FIGURES

• Figure 2.1: Segment of Double-Stranded DNA Showing the Base-Pair Relationship
• Figure 3.1: Global Market for DNA Sequencing
• Figure 4.1: Cepheid' s I-CORE Module

LIST OF TABLES

• Table 3.1: Global Market for DNA Sequencing
• Table 3.2: DNA Sequencing Market Players
• Table 3.3: Major DNA Product Companies in Europe
• Table 3.4: Major DNA Product Companies in Asia and Australia
• Table 3.5: Major DNA Product Companies in Japan
• Table 3.6: Major DNA Product Companies in Rest of the World
• Table 3.7: Market Revenue and Market Share of DNA Sequencing Market Players
• Table 3.8: Thermal Cyclers Marketed by Applied Biosystems
• Table 3.9: Applied Biosystems' Real-Time PCR Systems
• Table 3.10: Applied Biosystems Genetic Analysis Instruments
• Table 3.11: Gene Expression Assays Offered by Applied Biosystems
• Table 3.12: SNP Genotyping Assays Offered by Applied Biosystems
• Table 3.13: Comparison of Established Genomic Analysis Technologies
• Table 3.14: Life Science Techniques Frequently Used
• Table 3.15: The Most Commonly Used Reagents Used by Life Science Researchers
• Table 3.16: The Most Commonly Used Instruments and Apparatus in Life Science Research
• Table 3.17: The Most Widely Reported Categories of Software in Life Science Research
• Table 3.18: Reagents and Equipment Sales for Use in DNA Sequencing Worldwide
• Table 3.19: Global Market for Tools and Consumables Used in Drug Discovery and Development, Clinical Diagnostics and Biomedical Research
• Table 3.20: Key Bioassay Technologies in the Life Sciences Industry
• Table 3.21: Nucleic Acid Amplification Methods
• Table 3.22: Properties of Various Acid Amplification Techniques
• Table 3.23: Amplification Reagent Product Description
• Table 3.24: Standard Prep Pricing
• Table 3.25: Small Target Prep Pricing
• Table 3.26: Hybridization Pricing
• Table 3.27: Analysis Pricing
• Table 3.28: U.S. Market Size 2004-2010 in DNA Amplification Instrumentation
• Table 3.29: Market Share of Key Players in DNA Amplification Thermostable Enzymes
• Table 3.30: Leading Manufacturers of Thermal Cyclers and Market Share
• Table 4.1: ThermoFisherMolecular Biology Thermal Cyclers
• Table 4.2: PCR Systems and Thermocyclers
• Table 5.1: RiboMaker™ Assays to be Introduced for Cancer and Pathogen Detection
• Table 8.1: The Key Bioassay Technologies in the Life Sciences Industry