Nanotechnology: Emerging Healthcare Applications & Markets

Table of Contents

1 Executive Summary

• 1.1 Scope and Objectives of Report
• 1.2 Target Audience
• 1.3 Report Methodology
  • 1.3.1 Interviews with Clinical, Technical, and Market Experts
  • 1.3.2 Secondary Data Sources
• 1.4 Market Summary

2 Introduction to Nanotechnology

• 2.1 Perspective on Nanotechnology
  • 2.1.1 Definition(s) of Nanotechnology
• 2.2 Drivers of Medical Nanotechnology
  • 2.2.1 Microscopy
  • 2.2.2 Nucleic Acid Diagnostics/Molecular Diagnostic Assays
  • 2.2.3 Point-Of-Care Testing
  • 2.2.4 Genomics, Proteomics, DNA Biochips, and Microarrays
  • 2.2.5 Self-Assembly
  • 2.2.6 Tissue Engineering and Regenerative Medicine
• 2.3 Limiters of Medical Nanotechnology
• 2.4 The Healthcare Environment
  • 2.4.1 Funding and Commercialization
  • 2.4.2 U.S. Government Funding
  • 2.4.3 European and Asian Government Funding
  • 2.4.4 Venture Capital
  • 2.4.5 Market Structure
  • 2.4.6 Regulatory Environment
  • 2.4.7 Marketing
• 2.5 Notable Nanotechnology Materials
  • 2.5.1 Dendrimers
  • 2.5.2 Carbon Nanotubes
  • 2.5.3 Fullerenes

3 Clinical Diagnostics and Imaging

• 3.1 Role of Nanotechnology
  • 3.1.1 Objectives and Advantages
• 3.2 Nanoparticle Tagging and Nanoparticle Probes
  • 3.2.1 Qdots and Eviprobes: Quantum Dot Nanocrystals
  • 3.2.2 Nanobarcodes: Striped Metallic Nanoparticles (Nanoplex Technologies)
  • 3.2.3 Resonant Light Scattering Nanoparticles (Invitrogen)
  • 3.2.4 Gold Nanoparticle Probes (Nanosphere)
  • 3.2.5 Bioconjugated Nanoparticles (University of Florida)
• 3.3 Sensors
  • 3.3.1 Nanoparticle Tagging Systems
  • 3.3.2 Electronic Sensors
  • 3.3.3 Nanotube and Nanowire Sensors
  • 3.3.4 Single Molecule Detection
  • 3.3.5 Piezoelectric Acoustic Assays/Rupture Event Scanning (Akubio)
  • 3.3.6 Enzymatic Electrochemical Detection (GeneFluidics)
  • 3.3.7 Single-Molecule Sequencing and Analysis (Nanofluidics)
  • 3.3.8 Lab-on-a-Tape (Biotrove)
  • 3.3.9 Nanoarrays (BioForce Nanosciences, NanoInk)
  • 3.3.10 Dip Pen Nanolithography (NanoInk)
  • 3.3.11 Nano Mass Spectrometry (Advion BioSciences)
  • 3.3.12 NanoBreath (Nanotherapeutics)
  • 3.3.13 NanoGrid (Biogenon)
• 3.4 Imaging
  • 3.4.1 Quantum Dots
  • 3.4.2 Nano-Trimetaspheres (Luna Innovations)
  • 3.4.3 Dendrimers
  • 3.4.4 Tumor-Specific Nanoparticles (Kereos, Nanospectra Biosciences)
• 3.5 Instruments
• 3.6 Market Analysis

4 Therapeutics and Drug Delivery

• 4.1 Role of Nanotechnology
  • 4.1.1 Objectives and Advantages
• 4.2 Sustained Release
  • 4.2.1 Medusa System (Flamel)
  • 4.2.2 NanoGATE (iMEDD)
  • 4.2.3 Nanodry, Nanocoat (Nanotherapeutics)
  • 4.2.4 Fleximer (Nanopharma)
• 4.3 Solubility and Reformulation
  • 4.3.1 IDD, DissoCubes, SLN (SkyePharma)
  • 4.3.2 NanoEdge (Baxter)
  • 4.3.3 NanoCrystal (Elan Nanosystems)
  • 4.3.4 Precipitation With Compressed Antisolvent (CritiTech)
  • 4.3.5 Evaporative Precipitation Into Aqueous Solution (Dow Chemical Co.)
  • 4.3.6 High-Pressure Homogenization (PharmaSol)
  • 4.3.7 Controlled Flow Cavitation (Five Star Technologies)
  • 4.3.8 Transdermal Micellar Nanoparticles (Novavax and NanoCarrier)
  • 4.3.9 Bioral Technology (BioDelivery Sciences)
  • 4.3.10 PEGylated Nanoparticle Liposomes (ALZA)
  • 4.3.11 Polyvalent Liposome Nanoparticles (LigoCyte)
  • 4.3.12 BioVant Vaccine Adjuvant (BioSante)
• 4.4 Cancer Drugs With Modulated Targeting
  • 4.4.1 NanoShells (Nanospectra Biosciences)
  • 4.4.2 Magnetic Nanoparticles (Triton Biosystems vs. Nanobiotix)
• 4.5 Targeted Cancer Drugs Without Modulation
  • 4.5.1 Colloidal Gold TNF Nanoparticles (CytImmune Sciences)
  • 4.5.2 Atomic Nanogenerators (Dow Chemical Co., Sloan-Kettering)
  • 4.5.3 Micellar Nanoparticles (NanoCarrier, GlaxoSmithKline, Kirin, CTT)
  • 4.5.4 Lymph Node Drug Delivery (Nanopharma)
  • 4.5.5 Nanocrystallization (Ntera)
• 4.6 CNS Delivery: Crossing the Blood-Brain Barrier
  • 4.6.1 Nanocure (Advectus Life Sciences)
  • 4.6.2 NANODEL (NanoPharm)
• 4.7 General Targeting
  • 4.7.1 Dendrimers (Starpharma Pooled Development Fund)
  • 4.7.2 Targesome
  • 4.7.3 Poly Functional Nanoparticles (Alnis BioSciences)
• 4.8 Drug Delivery Implants
• 4.9 Nanomaterial Drugs
  • 4.9.1 Antioxidant and Anti-HIV Fullerenes (C Sixty)
  • 4.9.2 Antimicrobial Nanoemulsions (NanoBio)
  • 4.9.3 Rx Nanocrystals (NUCRYST Pharmaceuticals)
  • 4.9.4 RenaZorb (Altair Nanotechnologies)
  • 4.9.5 Nanotube Drug Research
• 4.10 Market Analysis

5 Biomedical Implants and Biomaterials

• 5.1 Role of Nanotechnology
  • 5.1.1 Objectives and Advantages
• 5.2 Surface Modification
• 5.3 Device Coatings
  • 5.3.1 Bandages
  • 5.3.2 Protective Coatings
  • 5.3.3 Stents
• 5.4 Tissue Engineering and Orthopedics
  • 5.4.1 NanoOss/Angstrom Medica
  • 5.4.2 Nanobone and Bone Cement
  • 5.4.3 Self-assembled Collagen Nanofibers
  • 5.4.4 Tissue and Organ Regeneration
  • 5.4.5 Wound Healing and Tissue Glues
  • 5.4.6 Bioactive Scaffolds
  • 5.4.7 Patterning and Nerve Growth
• 5.5 Other Devices
  • 5.5.1 Novel Organ-assisting Devices
  • 5.5.2 Brachytherapy
• 5.6 Market Analysis

6 Biomedical Research and Drug Discovery Tools

• 6.1 Role of Nanotechnology
  • 6.1.1 Objectives and Advantages
• 6.2 Drug Discovery Tools
  • 6.2.1 NanoMassSpectrometry
  • 6.2.2 Nanoarrays
  • 6.2.3 Nanolithography Arrays
  • 6.2.4 Living Chip (BioTrove)
  • 6.2.5 Congruent Force Intermolecular Test (Nanotype)
  • 6.2.6 Computer-Assisted Drug Discovery
• 6.3 Biological Research
• 6.4 Liquid Handling
• 6.5 Separation and Filtration
  • 6.5.1 Nanopore Sequencing and Separations
• 6.6 Market Analysis

7 Total World Market Summary

8 Future Applications: Nanoassembly and Beyond

• 8.1 Overview
• 8.2 Self-Assembly
• 8.3 Nanoassemblers
• 8.4 Cellular Interface and Implants
• 8.5 Nanobots

9 Company Briefs

• 9.1 Advion BioSciences Inc.
• 9.2 Angstrom Medica Inc.
• 9.3 BioForce Nanosciences, Inc.
• 9.4 Biophan Technologies, Inc.
• 9.5 C Sixty Inc.
• 9.6 Elan Nanosystems
• 9.7 Flamel Technologies S.A.
• 9.8 Invitrogen Corp.
• 9.9 NanoInk, Inc.
• 9.10 Nanoplex Technologies, Inc.
• 9.11 Nanospectra Biosciences, Inc.
• 9.12 NUCRYST Pharmaceuticals

10 Company Directory

List of Tables

• Table 2-1 Notable Nanotechnology Funding Requests by U.S. Institution/Department 2004
• Table 2-2 Nanotechnology Government Funding Estimates by Country 2003, 2004
• Table 3-1 Nanotechnology-based Products for Clinical Diagnostics and Imaging
• Table 3-2 Projected Commercialization of Nanotechnology-based Clinical Diagnostics and Imaging 2004-2008
• Table 3-3 World Market Size and Growth for Nanotechnology-based Diagnostics 2005-2007
• Table 4-1 Nanotechnology-based Products for Therapeutics and Drug Delivery
• Table 4-2 Projected Commercialization of Nanotechnology-based Therapeutics and Drug Delivery 2003-2011
• Table 4-3 World Market Size and Growth for Nanotechnology-based Therapeutics and Drug Delivery 2002-2007
• Table 4-4 World Market Size and Growth for Nanotechnology-based Drug Therapeutics 2002-2007
• Table 4-5 World Market Size and Growth for Nanotechnology-based Drug Delivery Services 2002-2007
• Table 4-6 Projected Sales of Nanotechnology-based Therapeutics and Drug Delivery by Product 2004-2007
• Table 5-1 Nanotechnology-based Products for Biomedical Implants and Biomaterials
• Table 5-2 Projected Commercialization of Nanotechnology-based Biomedical Implants and Biomaterials 2004-2008
• Table 5-3 World Market Size and Growth for Nanotechnology-based Biomedical Implants and Biomaterials 2002-2007
• Table 5-4 Projected Sales of Nanotechnology-based Biomedical Implants and Biomaterials by Product 2004-2007
• Table 6-1 Nanotechnology-based Biomedical Research and Drug Discovery Tools
• Table 6-2 Projected Commercialization of Nanotechnology-based Biomedical Research/Drug Discovery Tools 2004-2006
• Table 6-3 World Market Size and Growth for Nanotechnology-based Biomedical Research/Drug Discovery Tools 2002 2007
• Table 7-1 Total World Market Size and Growth for Biomedical Nanotechnology 2002-2007
• Table 8-1 Future Nanotechnology Applications

List of Figures

• Figure 3-1 World Market Size for Nanotechnology-based Diagnostics 2005-2007
• Figure 4-1 World Market Size for Nanotechnology-based Therapeutics and Drug Delivery 2002-2007
• Figure 4-2 World Market Size for Nanotechnology-based Drug Therapeutics 2002-2007
• Figure 4-3 World Market Size for Nanotechnology-based Drug Delivery Services 2002-2007
• Figure 5-1 World Market Size for Nanotechnology-based Biomedical Implants and Biomaterials 2002-2007
• Figure 6-1 World Market Size for Nanotechnology-based Biomedical Research/Drug Discovery Tools 2002-2007
• Figure 7-1 Total World Market Size for Biomedical Nanotechnology 2002-2007